Japan Vam & Poval Co., Ltd.

Masatoshi Kawanishi

Shotaro Kawada

Akinobu Oharuda

A novel binder is provided. The binder comprises a polyvinyl alcohol-based polymer which has an average saponification value of 85.0 mol % to 89.0 mol % as measured according to JIS K6726 and meets requirement (A): based on data obtained by measurement of the polyvinyl alcohol-based polymer by liquid chromatography, a value represented by formula (3) shown below is 22 or more,

Binder

Provided are a film coating composition containing a PVA having a degree of hydrolysis of 85.0 to 89.0 mol %, characterized in that even when the composition is used for coating of tablets without any additives other than PVAs, the tablets do not tend to stick to each other; a solid oral formulation using the composition; and a method for producing the same.

Film coating composition, solid oral formulation, and method for producing the same

Provided is a method for producing a polyvinyl alcohol resin, comprising the steps of copolymerizing an aliphatic vinyl ester (A) with diacetone acrylamide (B), at least a part of which diacetone acrylamide (B) is added at a later stage, in the presence of a polymerization catalyst in an alcohol solvent, so that the ratio (a)/(b) of the polymerization yield at the end of the polymerization (a) to the polymerization yield at the end of the later addition (b) of diacetone acrylamide (B) is in the range of 1.01 to 1.10, and saponifying the resulting copolymer.

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Osaka, Japan

Masatoshi Kawanishi