Merck Frosst Canada, Inc.

Bristol-Myers Company

Bristol-Myers Squibb Compnay

Mitsubishi Tanabe Pharma Corporation

Masatoshi Kakushima

Robert N Young

Toshikazu Oki

Maki Nishio

Joshua Rokach

Takeo Miyaki

Richard Frenette

Yosuke Sawada

Yvan Guindon

Masami Hatori

Tamotsu Furumai

Seikichi Kobaru

Haydn R Williams

Chiharu Ikeda

Masataka Konishi

Takayuki Kawaguchi

Robert J Zamboni

Thomas R Verhoeven

Kyoichiro Saitoh

Marshall Morningstar

Ila Sircar

Jacques-Yves Gauthier

Toshiyuki Kume

Hidefumi Kaji

Yoichiro Saitoh

The present invention relates to a compound of formula (I): wherein R is hydrogen atom, hydroxyl group or carbamoyl group, and n is 1 or 2, or a pharmaceutically acceptable salt thereof. 

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The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).

Production of pradimicin antibiotics

Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.

Method for treating fungal infections with serine analogs of BU-3608

Actinomadura hibisca microorganism useful for preparing serine analogs

Serine analogs of BU-3608 antibiotics

Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

Leukotriene antagonists

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reaction substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents.

BU-3608 derivatives

Compounds having the formula I: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.

The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio -.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.

Stereoselective synthesis of leukotriene antagonists

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

4-oxo-benzopyran carboxylic acids

Growing community of inventors

Yokohama, Japan

Masatoshi Kakushima