Sankyo Company, Limited

Masatoshi Inukai

Tatsuo Haneishi

Takeshi Kinoshita

Keiko Shimizu

Yoshiharu Sakaida

Toshio Takatsu

Fujio Isono

Masakatsu Kaneko

Hitoshi Hotoda

Masaaki Kizuka

Shunichi Miyakoshi

Yasumasa Ogawa

Masatoshi Arai

Mutsuo Nakajima

Satoshi Ohya

Yukio Utsui

Yo Takiguchi

Mamoru Arai

Tatsuya Yano

Yasunori Muramatsu

Masaki Nakahara

Isshin Tanaka

Yasuhiro Itoh

The present invention relates to a compound of formula (I) (wherein Rand Rrepresent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, Rrepresents a hydrogen atom or a hydroxyl group, and Xand Xrepresent an oxygen atom or a sulfur atom, or a nitrogen atom which may be substituted), a pharmaceutically acceptable derivative thereof or a salt thereof. The present invention also relates to a pharmaceutical composition comprising a compound described above as an active ingredient for the prevention or treatment of bacterial infections. The present invention includes the use of a compound described above in order to prepare a medicament effective in the prevention or treatment of bacterial infections. The present invention is concerned with a method for the prevention or treatment of bacterial infections in warm-blooded animals comprising administering a pharmacologically effective amount of a compound described above to them 

Antibacterial compound

A microorganism strain which isFERM BP-5420 and processes for preparing compounds by cultivating such microorganism strain.

Strain of Streptomyces griseus

A compound of the following chemical structure (I) which exhibits antifungal activity and is useful in treating and preventing fungal infectious diseases:

Compounds having antifungal activity

Antimicrobial compounds

The process for producing mureidomycin A, B, C or D or a salt thereof by cultivating Streptomyces flavidovirens SANK 60486, FERM BP-1347, in a culture medium therefor and isolating mureidomycin A, B, C or D or a salt thereof from the cultured broth.

Fermentation process for preparing antibiotics mureidomycins A, B, C and

New antibiotics of the mureidomycin group have the formula ##STR1## wherein X represents the group ##STR2## and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formula

Antibiotics of the mureidomycin group, their preparation, and their

Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM P-8636, FERM BP-1347). These represent a wholly new class of antibiotics, which are valuable in the treatment of infections caused by a variety of bacteria, notably of the genus Pseudomonas.

Antibiotics called 'mureidomycins A, B, C, and D' and their therapeutic

New antibiotic substances named substance No. 17927A.sub.2 and substance No. 17927A.sub.1 produced by cultivation of substances No. 17927A.sub.2 and No. 17927A.sub.1 -producing microorganisms belonging to the genus Streptomyces as well as pharmaceutically-acceptable salts thereof. They have broad antibacterial activities and also .beta.-lactamase inhibitory action so that they show synergistic actions with known penicillins and cephalosporins.

Antibiotic substances No. 17927A.sub.1 and No. 17927A.sub.2 and process

Growing community of inventors

Matsudo, Japan

Masatoshi Inukai