Otsuka Pharmaceutical Factory, Inc.

Otsuka Pharmaceutical Company, Limited

Masatoshi Inai

Makoto Inoue

Shizuo Nakamura

Kinji Hashimoto

Fumio Shimizu

Yoshiaki Tsuda

Mitsuru Hirohashi

Yoshihito Yamamoto

Setsuro Fujii

Satoshi Yamada

Takashi Sakamoto

Kazuhiko Tsutsumi

Keisuke Miyajima

Keiichi Kawakami

Tetsuhiko Shirasaka

Setsuro Fujii, Deceased

Takeshi Yamauchi

Hiroshi Kiyokawa

Seiichiro Iguchi

Jun Kanaya

Kunihiko Tatsumi

Naosumi Kinoshita

Akiyo Abe

Rika Hamamoto

By Shinichiro Fujii, Successor

By Keiko Fujii, Successor

Shino Shinomiya

By Kaoruko Takada, Successor

Kazushi Nagao

Yoshifumi Chone

Kazunobu Kurisu

Akie Tanaka

Masako Moritake

Tadanao Shibutani

The invention relates to a bicarbonate-containing medical solution package. The package comprises a gas-permeable plastic container holding a bicarbonate-containing medical solution and a gas-impermeable plastic packaging member containing the gas-permeable plastic container. A carbon-dioxide atmosphere is established in the space between the container and packaging member. In addition, a pH indicating device is contained within the space between the container and packaging member. The pH indicating device is a gas-permeable plastic packet containing a bicarbonate-containing fluid (similar to the medical solution) and a pH indicator. The pH indicator undergoes a change in color in response to a change in pH of the fluid. Use of this package allows the easy monitoring of a change in pH and consequent aging of the medical solution due to prolonged storage or damage to the outer packaging member.

Package for container of liquid medicine containing bicarbonate and pH indicator

Indole derivatives

Pyrimidine derivatives, method of manufacturing the same, and androgen

Novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, having the activities for inhibiting bone calcium absorption, for lowering the blood level of calcium, as analgesics, for inhibiting secretion of the gastric juice. Pharmaceutical composition can be prepared by formulating, at least one of the novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, together with a proteolytic enzyme inhibitors and/or pharmaceutically acceptable acids. The pharmaceutical composition are quite effective as agents for curing hypercalcemia, for curing Peget's disease, for curing osteoporosis, analgetic agent, anti-ulcerative agent and the like.

Polypeptide derivatives and calcium metabolism improving agent

Novel synthetic polypeptide derivatives, i.e., novel calcitonin derivatives, having improved basic physiological activities of the corresponding natural calcitonins, i.e., the activity for lowering the blood level of calcium, the activity as an analgesic, as well as the activity for inhibiting the secretion of the gastric juice. Thus these synthetic calcitonins are effective as agents for curing hypercalcemia, analgetic agents, anti-ulcerative agents and the like.

Polypeptide derivatives

The invention relates to a salt selected from group consisting of alkali metal salts and alkaline earth metal salts of an optically active form of a 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine, a process for producing said optically active compound or salt thereof, and a pharmaceutical composition, such as an antipodagric agent, comprising an effective amount of the salt together with a pharmaceutically acceptable nontoxic carrier.

Salts of optically active 4-hydroxy-8(3-lower

Disclosed is a proline derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof. These derivatives have useful utilities such as activity of inhibiting angiotensin converting enzyme.

Proline derivatives

Growing community of inventors

Tokushima, Japan

Masatoshi Inai