Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Tokyo Institute of Technology

Masatoshi Hazama

Tsuneo Yasuma

Tsuneo Oda

Shigehisa Taketomi

Yu Momose

Yasuo Sugiyama

Shogo Marui

Nozomu Sakai

Kohei Notoya

Tsuyoshi Maekawa

Masaki Ogino

Guido Hanauer

Katsuhito Murase

Koki Kato

Asae Shintani

Norihisa Iwakami

Toru Kawamura

Sham Nikam

The present invention provides a TGF-&#x3b2; superfamily production/secretion promoter comprising a compound represented by the formula wherein Ris a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of dysautonomia, bladder dysfunction, hearing impairment, bone disease and the like.

TGF-&#x3b2; superfamily production/secretion promoter

The present invention provides a VDAC regulator comprising a compound represented by the formula (I): wherein Ris a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group; a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like.

Thiazole and oxazole VDAC regulator

The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NR&#x2014;, &#x2014;CONR&#x2014; or &#x2014;NRCO&#x2014; (Ris a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; Ris an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be &#x2014;O&#x2014;, or a salt thereof.

Agent for preventing or treating neuropathy

The present invention provides a compound represented by the formula (I) wherein Ris a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group,

Azole compounds

Condensed 4,5,6,7-tetrahydrobenzo&lsqb;C&rsqb;thiophenes as enhancer for cell differentation induction factor action

Condensed 4,5,6,7-tetrahydrobenzo&lsqb;C&rsqb;thiopenes as enhancer for cell differentiation induction factor action

Cell differentiation inducing amide derivatives, their production and use

Condensed 4,5,6,7-tetrahydrobenzo&lsqb;C&rsqb;thiophenes as enhancer for cell differentiation induction factor action

A compound represented by the formula: ##STR1## wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R.sup.1 represents an optionally substituted hydrocarbon group; R.sup.2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.

Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell

Naphtholactams and lactones as bone morphogenetic protein active agents

Growing community of inventors

Ikeda, Japan

Masatoshi Hazama