Unicharm Corporation

Ribomic Inc.

Otsuka Pharmaceutical Company, Limited

Fujimoto Pharmaceutical Corporation

Cellmid Limited

Masatoshi Fujiwara

Yoshinori Tanaka

Akemi Tsuchiya

Tomokazu Suda

Yoshikazu Nakamura

Shin Miyakawa

Yasuhiko Kenmochi

Gregory Clegg Spooner

Hoss Vong

Takashi Matsui

Sadatoshi Sakuma

Akio Suzumura

Kouzou Abe

Jinyan Wang

Kenji Kadomatsu

Johannes Lambertus Maria Mensink

Kodai Furuya

Ling Jin

Hiroyuki Inagaki

Hisanao Hiramatsu

Hirokuni Ono

Yoshiko Saida

Miyuki Hirayama

Eiji Umemura

Ping Mu

Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

Aptamer for NGF and use thereof

The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): whereinX1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond,X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, andX3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T.

Aptamer against midkine and applications thereof

The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Methods for treatment or prevention of diseases associated with functional disorder of regulatory T cells

Method for treatment or prevention of disease associated with functional disorder of regulatory T cell

Provided is a high-quality aptamer against midkine. An aptamer possessing an inhibitory activity against midkine; a complex comprising an aptamer possessing a binding activity or inhibitory activity against midkine and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like); a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, labeling agent and the like comprising an aptamer possessing a binding activity or inhibitory activity against midkine, or a complex comprising the aptamer and a functional substance; a cell migration inhibitor, a diagnostic reagent, a labeling agent and the like.

Aptamer against midkine and use thereof

Disclosed is a pipe handle including first and second pipes which are engaged together with a male coupling of the second pipe fitted into a female coupling of the first pipe. The first pipe has a larger inside diameter in the female coupling than in a main body adjacent to the female coupling. The second pipe has a continuous outer surface without any step between the male coupling and a main body adjacent to the male coupling. The main body of the first pipe and the main body of the second pipe has an equal or almost equal outside diameter.

Pipe handle and cleaning device using the same

The cleaning item of the present invention comprises: a brush part constructed from fibrous material; an inserted part with an inserted space into which a gripper is detachably inserted and which is formed by a pair of sheets, the inserted part being disposed in the brush part; and a joining member which joins the brush part and the inserted part.

Cleaning item

An indoor cleaning tool having a dry fibrous base material is provided. An antigenicity-reducing composition including an antigenicity-reducing component, an oil and a surfactant are applied to the fibrous base material. Preferably, the antigenicity-reducing component is an extract of anor aplant extracted with water or an organic solvent.

Cleaning tool

A cleaning implement includes a cleaning head having on a bottom a cleaning operation surface, a holding portion arranged on the side opposite the cleaning head, a pipe for coupling the cleaning head and the holding portion, and a valve opening and closing device provided to the pipe so as to be able to hold a first container for receiving a first fluid or a second container for receiving a second fluid. The holding portion includes a lever coupled to the valve opening and closing device so as to open and close a first valve of the first container or a second valve of the second container. A spout of a second ejection nozzle for ejecting the second fluid containing an allergen inactivator is located, for example, at a height of about 30 cm or more from the floor.

Cleaning implement

A cleaning implement includes a cleaning head having on the bottom a cleaning operation surface and a valve opening and closing device that is connected to the cleaning head and can hold a first container for receiving a first fluid or a second container for receiving a second fluid. The cleaning implement further includes a first circulation path through which the first fluid is ejectable from the cleaning head and a second circulation path through which the second fluid is ejectable by interrupting the first circulation path.

A cleaning implement includes a cleaning head having a cleaning operation surface on a bottom, a holding portion arranged on the side opposite the cleaning head, a pipe for coupling the cleaning head and the holding portion, and a valve opening and closing device provided to the pipe so as to be able to hold a first container for receiving a first fluid or a second container for receiving a second fluid. The holding portion includes a lever coupled to the valve opening and closing device so as to open and close a first valve of the first container or a second valve of the second container. A first ejection nozzle can eject the first fluid forward of the cleaning head, and a second ejection nozzle can eject the second fluid rearward of the cleaning head.

Disclosed is a cleaning device with a squirter for squirting liquid forward of a cleaning head. The cleaning head has a nozzle head with a nozzle. A liquid receiving part is provided to extend from beneath an orifice of the nozzle toward a front face of the cleaning head. Liquid dripping from the orifice of the nozzle can be led down an inclined top face of the liquid receiving part to the outside of the cleaning head, preventing the cleaning head from being soiled with a detergent, a wax or the like.

Cleaning device with squirter

There is disclosed a cleaning article including a brush portion. The brush portion has a plurality of strips and at least one layer of a fiber bundle.

Cleaning article

A cleaning device with a squirter for squirting liquid forward of a cleaning head is provided. The cleaning head may have a nozzle head whose squirt surface is curved. In the nozzle head, squirt directions of nozzles, which are arranged to fan out at a squirt angle, may be substantially perpendicular to tangents to the squirt surface. Therefore, liquid squirted from the nozzles may fly straight along the squirt directions without being drawn to the squirt surface.

Growing community of inventors

Kagawa, Japan

Masatoshi Fujiwara