Toyota Jidosha Kabushiki Kaisha

Takeda Pharmaceutical Company Limited

Aisin Aw Co., Ltd.

Ricoh Company, Ltd.

Nec Platforms, Ltd.

Masato Yoshikawa

Nobufusa Kobayashi

Tatsuki Koike

Haruhi Ando

Kenta Kumazaki

Tooru Matsubara

Kazuyuki Shiiba

William John Farnaby

Takahiko Taniguchi

Tomoaki Hasui

Takeshi Kitahata

Naoki Nakanishi

Hiromichi Kimura

Kazuomi Okasaka

Takahiro Kimura

Daisuke Suyama

Jun Kunitomo

Toshio Sugimura

Keisuke Imamura

Eiji Honda

Makoto Fushimi

Mitsuru Maeda

Toshiya Nishi

Kasei Miura

Takeshi Yamamoto

Hideyuki Sugiyama

Masahiro Ito

Makoto Kamata

Naoki Ishii

Masayuki Baba

Jun Goto

Masaki Daini

Keiko Kakegawa

Hiroshi Nara

Atsushi Kayukawa

Morihisa Saitoh

Tomohiro Seki

Akira Kaieda

Yoshihisa Nakada

Masaki Seto

Shun Sato

Yuichi Kajita

Masashi Toyofuku

Eiji Kimura

Takaaki Tanaka

Shuhei Ikeda

Akito Shibuya

Zenyu Shiokawa

Michiyo Mochizuki

Shinichi Sasade

Yusuke Tominari

Munehiro Katsumata

Kosuke Hidaka

Kousuke Hidaka

Yayoi Nakayama

Yasuo Nakagawa

Hiromi Fukuda

Seiji Kuwahara

Tsuneo Oda

Takahiko Tsutsumi

Shinkichi Suzuki

John Frederick Quinn

Yoshiteru Ito

Shintaro Matsutani

Koki Minamikawa

Yusuke Sasaki

Mitsuru Yamaguchi

Joseph Raker

Paul D Greenspan

Koji Sugiyama

Brian Scott Freeze

Yasufumi Wada

Hisashi Ishihara

Taisuke Tawaraishi

Hironobu Aratake

Izumi Nomura

Norimi Asahara

Takuto Kojima

Yasuyuki Kato

Yasuyoshi Arikawa

Tomohiro Okawa

Minoru Sasaki

Hironobu Maezaki

Yasutomi Asano

Ayumu Sato

Tohru Miyazaki

Hiroya Tanaka

Jinichi Yonemori

Yasuhiro Imaeda

Suguru Sangu

Masanori Okaniwa

Fumiaki Kikuchi

Hiromasa Tatsushiro

Misaki Homma

Akinori Toita

Akihito Hayasaka

Takatoshi Yogo

Hironori Kokubo

John F Quinn

An electronic control unit includes processing circuitry. A hybrid electric vehicle has an electric traveling mode, in which the hybrid electric vehicle travels with a system clutch disengaged and an engine in a stopped state, and a hybrid traveling mode, in which the hybrid electric vehicle travels with the system clutch engaged and engine operating. The processing circuitry is configured to control, when the traveling mode is switched from the electric traveling mode to the hybrid traveling mode, a throttle opening degree of the engine at the time of completion of engagement of the system clutch in accordance with the atmospheric pressure such that a constant intake air amount is obtained regardless of the level of the atmospheric pressure.

Vehicle controller and vehicle control method

The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Heterocyclic compound

A control apparatus for a vehicle that includes an engine, an electric motor and a clutch provided between the engine and the electric motor. An engine-start delay control is executed in a case in which a requested drive amount is realized by only a torque of the electric motor and a first starting manner is being selected as an engine starting manner. Then, in a case in which a predetermined time elapses from initiation of the engine-start delay control, the engine-start delay control is terminated and the engine is started in the first starting manner. On the other hand, in a case in which the engine starting manner is switched from the first starting manner to a second starting manner before the predetermined time elapses from the initiation of the engine-start delay control, the engine-start delay control is terminated and the engine is started in the second starting manner.

Control apparatus for vehicle

A controller is employed in a vehicle including an engine, a motor generator, and a hydraulically-driven clutch. The controller includes a CPU that executes: a first starting process that starts, when starting the engine under a condition in which a system shaft torque is less than a shaft torque determination value, combustion in the engine after increasing an engine rotation speed to a motor rotation speed by engaging the clutch; a second starting process that starts, when starting the engine under a condition in which the system shaft torque is greater than or equal to the shaft torque determination value, combustion in the engine after the crankshaft starts to be rotated by engaging the clutch, the combustion being started before the engine rotation speed reaches the motor rotation speed; and a setting process that sets the shaft torque determination value to be larger as an oil temperature becomes lower.

Controller and control method for hybrid electric vehicle

A hybrid electric vehicle including: (a) an engagement device disposed between an engine and an electric motor; (b) a transmission disposed between the electric motor and drive wheels; (c) an electric storage device configured to supply an electric power to the electric motor; and (d) a control apparatus. When the engine is to be started, the engagement device is engaged to transmit a torque from the electric motor to the engine, for thereby starting the engine. The control apparatus is configured to inhibit stop of the engine, when an outputtable electric power outputtable from the electric storage device is not larger than a threshold value. The threshold value is not smaller than a start-case-required electric power that is required to start the engine, such that a difference value between the threshold value and the start-case-required electric power is not larger than a predetermined value.

Hybrid electric vehicle

An optical device, a method of detecting the degree of inclination of a three-dimensional object, and a method of detecting a line of sight. The optical device includes a plurality of light emitters configured to irradiate an object with light, a detector configured to detect the light reflected by the object and output a signal based on the light reflected by the object, and circuitry configured to output data of a degree of inclination of the object obtained based on an output signal output from the detector. In the optical device, the light emitted from the light emitter is temporally modulated by a code having orthogonality, and the plurality of light emitters include a first light emitter and a second light emitter. In the optical device, the first light emitter emits the light at a timing different from a timing at which the second light emitter emits the light.

Optical device, line-of-sight detection device, retinal projection display device, head-mounted display, optometric device, user-condition estimation apparatus, driver-assistance system, method of detecting degree of inclination of three-dimensional object, and line-of-sight detection method

A hybrid electric vehicle includes an engine, a motor, a clutch provided between the engine and the motor, a battery for charging regenerative electric power of the motor, and a control device that controls the engine, the motor, and the clutch. The control device includes a charge determination unit that determines whether the battery is chargeable when there is a deceleration request, and a deceleration control unit that executes, in a negative determination, a first deceleration process to decelerate the hybrid electric vehicle by friction torque of the engine, and executes, in a positive determination, a second deceleration process to decelerate the hybrid electric vehicle by regenerative torque of the motor. In the second deceleration process, the deceleration control unit causes the motor to output the friction torque at a rotational speed of the engine corresponding to a rotational speed of the motor as the regenerative torque.

A controller is employed in a vehicle including an engine, a motor generator, and a hydraulically-driven clutch. The controller includes a CPU that executes: a first starting process that starts, when starting the engine under a condition in which an increase amount of a torque request value is less than an increase amount determination value, combustion in the engine after increasing an engine rotation speed to a motor rotation speed by engaging the clutch; and a second starting process that starts, when starting the engine under a condition in which the increase amount of the torque request value is greater than or equal to the increase amount determination value, combustion in the engine after the crankshaft starts to be rotated by engaging the clutch, the combustion being started before the engine rotation speed reaches the motor rotation speed.

The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Methods of making a cyclic dinucleotide

The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

A hybrid vehicle controller for controlling a hybrid vehicle including a hybrid system is provided. The hybrid system includes an engine, a motor generator, a battery configured to supply power with the motor generator, a clutch configured to connect the engine to the motor generator, and a relay configured to connect the motor generator to the battery. The hybrid vehicle controller includes processing circuitry. The processing circuitry is configured to execute, when an operation requesting opening of the relay is performed, a process that releases the clutch, a negative torque application process that applies a negative torque, which is a torque for lowering a rotational speed of the motor generator, to the motor generator, after releasing the clutch, and a process that releases the relay when the rotational speed of the motor generator becomes less than a threshold.

Hybrid vehicle controller

In a driven state phase, target input torque is limited to a first limit value, whereas in a backlash-elimination state phase, the target input torque is limited to a second limit value and target engine torque and torque of a motor-generator are controlled according to the target input torque. In the backlash-elimination state phase, the target input torque is limited to the second limit value that is suitable for mitigating rattling shock, so that rattling shock can be appropriately mitigated. Meanwhile, in the driven state phase, the target input torque is limited to the relatively high first limit value, so that an MG rotation speed can be quickly increased to eliminate a rotational difference, which enhances the responsiveness of driving power up to when required driving power is obtained after elimination of the backlash.

Vehicle control device

Antibody-drug conjugates comprising a cyclic dinucleotide

A control device of a hybrid vehicle including an engine, motor that receives power from the engine via an engine connecting and disconnecting device, and automatic transmission, starts the engine in a first starting method in which the engine performs ignition and rotates by itself after the engine speed is increased to be equal to or higher than a predetermined rotational speed through slipping engagement of the engine connecting and disconnecting device, or a second starting method in which the engine performs ignition and rotates by itself from a stage before the engine speed reaches the predetermined rotational speed, and controls the automatic transmission to permit a lower gear position to be established according to shift conditions when the engine is started in the second starting method during a downshift of the automatic transmission, as compared with when the engine is started in the first starting method during the downshift.

Control device of hybrid vehicle

Growing community of inventors

Kanagawa, Japan

Masato Yoshikawa