Passport Technologies, Inc.

Fuji Photo Film Company, Limited

Kirin Brewery Company, Limited

San-ei Chemical Industries, Ltd.

Nitto-denko Corporation

Masato Nishimura

Hirotoshi Adachi

Shohei Horie

Joe Hua

Akinori Hanatani

Yuki Yamada

Shigeru Matsuo

Masamitsu Moriwaki

Hiroshi Horikawa

To provide a transdermal drug delivery patch that can be suitably used for an immediate release application of a pharmaceutical with a comparatively low molecular weight. A transdermal drug delivery patch, provided with a matrix and at least one drug disposed within the matrix, wherein the matrix has a water holding capacity of 10 mg/cmor less, and the drug is a pharmaceutical having a molecular weight of 5000 or less.

Transdermal drug delivery patch, drug delivery system and drug delivery

A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.

Triptan microporation delivery system

A bioreactor apparatus for producing metabolites from bioorganisms by depositing the animal cells on a carrier made of a porous material. The apparatus includes a hermetically sealed container (1) having a first supply channel A, for supplying a liquid containing animal cells into the inside thereof, a second supply channel (B) for supplying a culture solution and a substrate solution into the inside thereof, a first exhaust channel (a) for exhausting a liquid containing suspended animal cells from the inside thereof, and a second exhaust channel (b) for exhausting a residual part of the culture solution, a residual part of the substrate solution and a solution containing metabolites of the animal cells from the inside thereof. Disposed within the container is an animal culture base including a porous carrier (31, 33, 34) and a culture bed (4) arranged so that liquid supplied from the supply channels (A, B) are brought into contact therewith while flowing in the inside of the container (1). Further, the apparatus includes a filtration membrane (6) arranged across the second exhaust channel (b) in the inside of the container (1) and provided for filtrating a liquid to be exhausted through the second exhaust channel (b).

Bioreactor apparatus

A process for dissolving a sparingly water-soluble flavonoid in an aqueous medium by use of one or more kinds of quercetin-3-0-glycosides, which is applicable to the case of using the sparingly water-soluble flavonoid as an antifading agent for colored drinks.

Composition and process for dissolving a sparingly water-soluble

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Osaka, Japan

Masato Nishimura