Taiho Pharmaceutical Company Limited

Masato Nanri

Kazuo Ogawa

Ichiro Yamawaki

Junji Yamamoto

Nobuo Kasahara

Fukumitsu Sakakibara

Manabu Kaneda

Takashi Arima

Shinichi Aoki

Yoshikazu Iwasawa

Kazuharu Noguchi

An acetic acid ester compound represented by the following formula (I) or a salt thereof, wherein R represents optionally substituted deuterated lower alkyl, is disclosed.

Acetic acid ester compound or salt thereof

A benzilic acid ester compound represented by the following formula (I) or a salt thereof, 

Fluorinated benzilic acid ester compound and salt thereof

An object to be solved by the present invention is to provide a superior prophylactic agent and/or therapeutic agent for stress urinary incontinence. The present invention provides a prophylactic agent and/or a therapeutic agent for stress urinary incontinence comprising an effective amount of 4-piperidyl diphenylpropoxyacetate or a salt thereof, and a pharmaceutical carrier.

Prophylactic agent and/or therapeutic agent for stress urinary incontinence

Bicyclolactam compounds, use thereof and intermediates for preparing thereof

Bicycloloactam compounds, use thereof and intermediates for preparing thereof

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2##

Bicyclolactam compounds, use thereof and intermediates for preparing

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2## .

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Tsukuba, Japan

Masato Nanri