Nihon Medi-physics Company, Limited

Hokkaido University

Tokyo Institute of Technology

Masato Kiriu

Yuki Okumura

Yuji Kuge

Hiroshi Tanaka

Naomi Sugimoto

Masahito Toyama

Daisaku Nakamura

Hiroki Matsumoto

Norihito Nakata

Soichi Nakamura

Hiroaki Ichikawa

Gota Tonoya

Eriko Nagata

Songji Zhao

Ken-Ichi Nishijima

Norifumi Abo

Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains the radiohalogen-labeling precursor compound (S-L) and a reaction product (S&#x2014;X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S&#x2014;X) is purified from the reaction mixture RM2 by a solid phase extraction method.

Method for producing radiohalogen-labeled compound and method for producing radiopharmaceutical

A simple method for producing a clinically applicable radiopharmaceutical composition containing 1-(2,2-dihydroxymethyl-3-[F]fluoropropyl)-2-nitroimidazole ([F]DiFA) or a salt thereof as an active ingredient, is provided which includes a synthesis step of obtaining a crude product of [F]DiFA from a labeling precursor compound for [F]DiFA; and a purification step of purifying the crude product, in which the purification step includes purifying [F]DiFA using two or more different types of reverse phase solid phase extraction cartridges.

Method for producing radiopharmaceutical composition

There is provided a labeling precursor compound represented by the following general formula (2): wherein Rrepresents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a monocyclic or condensed polycyclic aryl group or a nitrogen-containing heterocycle; Rand Reach independently represent an alkyl group or a hydroxyalkyl group which hydroxy group may be protected with a protecting group, and n is an integer of 1 or 2; Rrepresents an alkyl group or &#x2014;CONRRwherein Rand Reach independently represent an alkyl group or a monocyclic or condensed polycyclic aryl group; and R, R, Rand Reach independently represent a hydrogen atom, an alkyl group or an alkoxy group.

Radioactive fluorine labeling precursor compound and method for manufacturing radioactive fluorine labeled compound using the same

The present invention is a compound represented by the following formula (1) or a salt thereof. In the formula (1), Rdenotes a hydrogen atom, a methyl group, or a hydroxymethyl group, and n is an integer of 1 or 2. 

Radioactive fluorine-labeled compound

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Tokyo, Japan

Masato Kiriu