Pola Chemical Industries, Inc.

Pola Chemical Industries Inc., Japan

Masato Inazu

Toshihiro Morimoto

Takeshi Yamamoto

Makoto Kimura

Takayuki Namiki

Kenichi Kishii

Masayuki Yanagi

Nobuyuki Kawakatsu

Yuji Yoshiko

Kazunori Harada

Yoshiyuki Miyata

Masaki Mitani

Mariko Harada

Ryoko Yokota

Tetsuo Katoh

Michihiko Tsujitani

Kyoko Yamasaki

Mariko Onoda

Yoshiaki Motoki

Tomoko Masuda

Ichiro Matsuo

Yoshiharu Momota

A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R.sup.1 and R.sup.2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R.sup.3 represents a hydrogen atom, an alkyl group, or an acyl group; R.sup.4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided. The medicament is effective in the prevention and treatment of narcosic dependence due to cocaine, etc.

Narcotic antagonist

Dopamine re-uptake inhibitor

Diphenylpiperazine derivative and drug for circulatory organ containing

Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed. The compounds are represented by the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 individually represent a hydrogen atom, a linear or branched alkyl group which may have a substituent, a cycloalkyl or phenyl group which may have a substituent, or a heterocyclic group which may have a substituent, and R.sub.3 is a hydrogen atom or a cyano group. The compounds have excellent circulatory disease curing activities as well as bronchodilation activities.

Pyrrolo(3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine

Growing community of inventors

Yokohama, Japan

Masato Inazu