Nisshin Flour Milling Co., Ltd.

Masato Horigome

Katsutoshi Miura

Toshihiro Takahashi

Koichi Nakamaru

Hitoshi Inoue

Masanori Sugita

Masao Nagase

Kenichi Momose

Shinji Nagai

Kouichi Katsuyama

Chikako Suzuki

Hiroyasu Koyama

Makoto Yanai

Norio Oshida

Shigeru Hiramoto

Noriyoshi Sueda

Hiroaki Yamada

Nobuhiro Kinoshita

Toshiji Sugai

Einosuke Sakurai

Kazuhiko Yamada

Yoko Tsukada

Fumihisa Nakata

Koichi Katsuyama

Koichi Katasuyama

Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Urea derivatives and their use as ACAT inhibitors

Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R; R represents pyridyl or substituted amino of NR.sub.1 R.sub.2 ;

Indole derivatives

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R;

Disclosed are indole derivatives of formula (I) ##STR1## wherein Y represents H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or halogen;

Indole derivatives and anti-ulcer compositions thereof

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.3 alkyl or diphenylmethyl; Y is --NH(CH.sub.2).sub.n --R.sub.2 ; R.sub.2 is OH or --ONO.sub.2 ; m is 2 or 3; and n is 9 to 13 or physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing and hypotensive actions and can be used for the therapy or prevention of diseases in the cardiovascular system.

Pyridinecarboxylic acid amide derivatives and pharmaceutical

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen; C.sub.1 -C.sub.6 alkyl; C.sub.3 -C.sub.6 cycloalkyl or diphenylmethyl;

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Tokyo, Japan

Masato Horigome