Sekisui Kagaku Kogyo Kabushiki Kaisha

Chugai Seiyaku Kabushiki Kaisha

Eisai Company, Limited

Nippon Oil Fats Co., Ltd.

Sanwa Kagaku Kenkyusho Co., Ltd.

Sansho Co., Ltd.

Masato Azuma

Masayasu Kurono

Makoto Sato

Mitsuhiro Yoshida

Tsutomu Ishida

Mutsumi Fukuda

Takashi Nakagawa

Hiroyuki Fujimori

Hiroko Tsukahara

Kazushi Tokita

Tsutomu Negama

Yasuaki Kawano

Katsuhiko Takahashi

Toshihiro Inoue

Satoshi Uenoyama

Hiroshi Kuroda

A pharmacological composition for percutaneous administration to a human patient comprises a pharmacologically effective amount of eperisone, a salt thereof, tolperisone or a salt thereof, a water-swellable crosslinked polyvinylpyrrolidone and a base carrier, and exhibits improved percutaneous absorption.

Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or

A pharmaceutical preparation for percutaneous absorption comprising a base material and fine crystals of Nicorandil and/or salts of Nicorandil that are evenly distributed throughout said base material and that have a mean diameter of 2 .mu.m or more, and a method for preparing the same.

Pharmaceutical preparation for administration by percutaneous absorption

A percutaneous pharmaceutical preparation in tape form is provided. The preparation comprises a flexible backing, which is not permeable to an active ingredient, and an adhesive layer formed on the flexible backing, the adhesive layer comprising an adhesive base material and an active ingredient compatible with the adhesive base material, wherein the adhesive base material consists essentially of a copolymer containing 2-ethylhexyl acrylate in a concentration of 45 to 80 mol % and N-vinyl-2-pyrrolidone in a concentration of 20 to 55 mol %, and the active ingredient is estradiol and/or the esters thereof which are contained in a concentration of 6 to 25% by weight of the total amount of the adhesive base material and the active ingredient.

Percutaneous pharmaceutical preparation

A percutaneous-administration-type pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.

Percutaneous-administration-type pharmaceutical preparation of

Growing community of inventors

Osaka, Japan

Masato Azuma