Nisshin Flour Milling Co., Ltd.

Masato Ariga

Yukio Saito

Koichi Katsuyama

Shigeo Hatanaka

Toshihiro Takahashi

Kenichi Momose

Nobutake Kimura

Hirohito Yamakawa

Yoshio Nakagawa

Akio Shimizu

A hairless mouse designated NS:Hr/ICR is sensitive to H. pylori. This NS:Hr/ICR hairless mouse can be easily infected with H. pylori in its alimentary canal, and is therefore useful as an experimental animal model for H. pylori infection.

Hairless mouse sensitive to helicobacter pylori

The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1.beta. and the release of TNF.alpha.. Those derivatives are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis.

Agents for inhibiting the production of IL-1.beta. and the release of

Diphenyl disulfide compounds having an inhibiting activity against the production of Interleukin-1.beta. (IL-1.beta.) or the release of Tumor Necrosis Factor.alpha. (TNF.alpha.), which are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis are described.

Diphenyl disulfide compounds

Growing community of inventors

Ohimachi, Japan

Masato Ariga