Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Masataka Ueno

Kohshi Ueno

Satoshi Nagato

Masahiro Yonaga

Kunizo Higurashi

Hachiro Sugimoto

Isao Saito

Koichi Ito

Koki Kawano

Noritaka Kitazawa

Akiharu Kajiwara

Takaharu Nakamura

Kiyomi Yamatsu

Norio Karibe

Takeru Kaneko

Shinji Hatakeyama

Takahiro Nakazawa

Takahisa Hanada

Makoto Komatsu

Yoshimasa Machida

Norio Minami

Naoyuki Shimomura

Yoshiharu Yamanishi

Yoshihiko Norimine

Kozo Akasaka

Toshikazu Shimizu

Yuki Komatsu

Masuhiro Ikeda

Terence Smith

Hiroyuki Amino

Anthony John Groom

Leanne Rivers

Atsushi Nagaoka

Makoto Ogo

Kunizou Higurashi

Yoshio Urawa

Hiroyuki Naka

Tatsuto Fukushima

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.  In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, manufacturing method thereof and use thereof

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Heterodiazinone derivatives

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:

Biphenyl derivatives

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.

A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --0--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat a mental symptoms associated with a cerebrovascular disease.

Cyclic amine and pharmacological composition

A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat mental symptoms associated with a cerebrovascular disease.

Piperidine compounds useful to treat cerebrovascular diseases

Cyclic amine derivatives

Growing community of inventors

Ibaraki, Japan

Masataka Ueno