The University of Tokyo

Microbial Chemistry Research Foundation

Masataka Shiozuka

Ryoichi Matsuda

Yoshikazu Takahashi

Akihiro Taguchi

Daishiro Ikeda

Masafumi Matsuo

Yoshio Hayashi

Yoshiaki Nonomura

Atsushi Nishida

Fumika Yakushiji

Yuri Yamazaki

Akira Wagatsuma

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Compound having read-through activity

A readthrough inducing agent for inducing readthrough of a premature stop codon generated by nonsense mutations, the readthrough inducing agent comprising a compound having a structure expressed by the following Structural Formula (A), and a drug for treating a genetic disease caused by nonsense mutations, the drug comprising the readthrough inducing agent. 

Readthrough inducing agent and drug for treating genetic disease caused by nonsense mutation

Growing community of inventors

Tokyo, Japan

Masataka Shiozuka