Sogo Pharmaceutical Co., Ltd.

Masataka Kuroki

Kazuyuki Shioka

Sadamitsu Kono

Saburo Uchikuga

Novel amidoxime derivatives having the following structural formula (IV) or (IV'): ##STR1## wherein R.sub.1 represents methyl or ethyl group and R.sub.2 represents hydrogen or methyl group, useful as a raw material for 3-amino-5-methyl isoxazole, are prepared from .beta.-amino crotonitrile. Said isoxazole, useful as an intermediate for various medicines, may be prepared without producing any by-products of isomer.

Novel amidoxime derivatives

Novel amidoxime derivatives having the following structural formula (IV) of (IV'): ##STR1## wherein R.sub.1 represents methyl or ethyl group and R.sub.2 represents hydrogen or methyl group, useful as a raw material for 3-amino-5-methyl isoxazole, are prepared from .beta.-amino crotonitrile. Said isoxazole, useful as an intermediate for various medicines, may be prepared without producing any by-products of isomer.

Amidoxime derivatives

Salt of pantothenic acid and salt of cystamine or cysteamine are caused to react under the presence of an accelerator selected from the group consisting of carbodiimides and N-hydroxy compounds without any pretreatment thereby producing pantethine or pantetheine, and the pantetheine is oxidized to produce pantethine which is a precursor of co-enzyme A.

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Sagamihara, Japan

Masataka Kuroki