Fujifilm Corporation

Other

Hoshi University

Swiss Tropical and Public Health Institute

Synstar Japan Co., Ltd.

Schweizerisches Tropen-und Public Health-institut

Ihara, Masataka

Masataka Ihara

Kozo Sato

Hiroshi Kitaguchi

Masayuki Kawakami

Khanitha Pudhom

Isamu Itoh

Kiyosei Takasu

Reto Brun

Jian-Feng Ge

Chika Arai

Nasser Saad Mohamed Ismail

Mei Yang

Kanitha Pudhom

Saad Mohamed Ismail Nasser

A rhodacyanine derivative represented by the following General Formula (1), wherein, in General Formula (1), R, R, and Reach independently represent an alkyl group which may be substituted; Yand Yeach independently represent a hydrogen atom, a chlorine atom, or a fluorine atom provided that Yand Ydo not represent hydrogen atoms at the same time; and X represents a counter anion. A pharmaceutical composition for treating leishmaniasis including the rhodacyanine derivative and a pharmaceutically acceptable carrier. 

Rhodacyanine derivative and pharmaceutical composition for treating leishmaniasis

Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.

Medicinal composition containing benzo[a]phenoxazine compound as the active ingredient for prevention or treatment of protozoal disease

The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or &#x2014;NR&#x2014; (Rrepresents an alkyl group, aryl group or heterocyclic group); L, L, L, Land Leach independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less).

Medicinal composition for prevention or treatment of parasitic protozoan infection

The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, Calkoxycarbonyl group or Calkylaminocarbonyl group, and may be bound to each other; R, R, and Reach independently represents a Calkyl group or Caryl group; Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, or Calkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).

Anti-trypanosomiasis agent

Growing community of inventors

Tokyo, Japan

Masataka Ihara