Ono Pharmaceutical Co., Ltd.

Masashi Shiota

Naohiro Kayama

Tsuyoshi Watanabe

Setsuro Fujii

Itsuo Okumoto

Seiei Sasatani

Yoshinori Ii

Yoshiaki Uegai

Okumoto Itsuo

Granules containing pranlukast, process for producing the granules, and

The guanidinobenzoic acid derivatives of the general formula: ##STR1## wherein Z represents a carbon-carbon covalent bond, or a methylene, ethylene or vinylene group, R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, R.sup.2 represents a straight- or branched-chain alkyl group containing from 4 to 10 carbon atoms, or a cycloalkyl or cycloalkenyl or straight- or branched-chain alkenyl group containing from 3 to 8 carbon atoms, or a phenyl or benzyl group, or NR.sup.1 R.sup.2 represents a 4- to 8-membered heterocyclic ring, and acid addition salts thereof, have anti-plasmin and anti-trypsin activities.

Guanidinobenzoic acid derivatives

Guanidinobenzoic acid derivatives represented by the general formula [I] ##STR1## wherein R.sup.1, R.sup.2 and Z are as defined hereinafter, having antiplasmin and anti-trypsin activities and process for their preparation as well as a pharmaceutical composition and a method of inhibiting the activity of plasmin and trypsin is disclosed.

Guanidinobenzoic acid derivatives and process for their preparation

Guanidinobenzoic acid compounds represented by the formula ##STR1## wherein R and Z are as defined hereinafter, having anti-plasmin and anti-trypsin activities and processes for preparing the same as well as a pharmaceutical composition and a method of inhibiting the activity of plasmin and a trypsin is disclosed.

Guanidinobenzoic acid compounds and process for preparing the same

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Nishinomiya, Japan

Masashi Shiota