Raqualia Pharma Inc.

Xuanzhu Pharma Co., Ltd.

Masashi Ohmi

Kazuo Ando

Yuji Shishido

Kiyoshi Kawamura

Tatsuya Yamagishi

Ryuichi Yamaguchi

Ryohei Magara

Mikio Morita

Hirohide Noguchi

Yasuhiro Iwata

Yoshimasa Arano

Masaki Sudo

Mikito Takefuji

Madoka Jinno

Yutaka Fukumoto

Takeshi Matsushita

The present invention relates to 3-hydroxyoxindole derivatives which have antagonistic activities against CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR2 is involved.

3-hydroxyoxindole derivatives as CRHR2 antagonist

The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.

Fused cyclic urea derivatives as CRHR2 antagonist

The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved. 

Biaryloxy derivatives as TTX-S blockers

The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor. 

Azaspiro derivatives as TRPM8 antagonists

The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPMb8 receptor. 

Sulfamoyl benzoic acid heterobicyclic derivatives as TRPM8 antagonists

The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38). 

Oxyindole derivatives with motilin receptor agonistic activity

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Aichi, Japan

Masashi Ohmi