Sumitomo Pharmaceuticals Company Limited

Masashi Nakatsuka

Junki Katsube

Naohito Ohashi

Kikuo Ishizumi

Shunji Aono

Shoji Nagata

Gerard Robert Scarlato

Yumiko Kamikawa

Fumio Nishikaku

Yoshihide Ueno

Fumio Samizo

Sara Sabina Hadida Ruah

Tamiki Nishimura

Shin-ichiro Okada

Hitoshi Houtigai

Teruo Sakurama

A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor.

Hydroxamic acid derivatives

An isoxazole derivative represented by the formula: ##STR1## or a pharmaceutically acceptable salt thereof useful as a therapeutic drug for auto-immune diseases and inflammatory diseases.

Isoxazole derivatives

Novel phenylserine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions, and a process for preparing the compounds are disclosed. The phenylserine derivatives and pharmaceutically acceptable acid addition salts are capable of inhibiting the biosynthesis of leucotrienes and/or antagonistic activity against SRS-A and hence are useful for prophylaxis and treatment of various allergic diseases (e.g. bronchial asthma, allergic nasitis, urticaria), ischemic heart diseases, ischemic encephalopathy, inflammation, or the like.

Phenylserine derivatives and processes for preparing the same

Growing community of inventors

Osaka, Japan

Masashi Nakatsuka