Japan Science and Technology Agency

Riken Corporation

Osaka Bioscience Institute

Rigaku Corporation

Masashi Miyano

Yoshihiro Urade

Osamu Hayaishi

Naomi Eguchi

Akihito Yamano

Kensaku Hamada

Kosuke Aritake

Ikuko Mori

Yousuke Okano

Shigehiro Kinugasa

Hiroyoshi Matsumura

Daisuke Irikura

Masaki Yamamoto

Masako Taniike

Yasushi Kai

Takashi Kumasaka

Tsuyoshi Inoue

Yo Sato

A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.

Three-dimensional structure of prostaglandin D synthase and utilization thereof

An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.

Method for treating myolytic disease and method for screening antimyolytic agent

Growing community of inventors

Ibo-gun, Japan

Masashi Miyano