Toray Industries, Inc.

Masashi Kodama

Kazuo Teramoto

Toru Tani

Shiro Nishiumi

Totaro Oka

Kazuyoshi Hanazawa

Mutsuo Murakami

By Shigemasa Katayama, Heir

Yutaka Katayama, Deceased

By Nobuko Katayama, Heir

By Yoshimasa Katayama, Heir

Lipopolysaccharides derived from the cell walls of Gram-negative bacteria, also known as endotoxins or pyrogens, are immobilized on a solid, insoluble carrier. The blood, blood plasma or blood serum of a tumor-bearing patient is passed over the immobilized lipopolysaccharide-containing blood treating material to treat the patient's tumor.

Method of treating malignant tumors

The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed. The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy endotoxemia or prophylaxis of endotoxemia.

Endotoxin detoxifying material

The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed. The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.

Endotoxin detoxifying process

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Kusatsu, Japan

Masashi Kodama