Toppan Printing Co., Ltd.

Matsushita Electric Industrial Co., Ltd.

Shimano Inc.

Sumitomo Dainippon Pharma Co., Ltd.

International Institute of Cancer Immunology, Inc.

Panasonic Corporation

Joled Inc.

Sumitomo Pharma Co., Ltd.

Panasonic Intellectual Property Management Co., Ltd.

Nissin Foods Holdings Co., Ltd.

Sunstar Inc.

Hirosaki University

Sapporo Medical University

Masashi Goto

Mikihiko Nishitani

Hitoshi Ban

Noriyuki Sasaki

Yosuke Takanashi

Jun Araki

Shunsuke Yajima

Yukihiro Nishio

Motoo Yanagiuchi

Chiang Jia Li

Toshio Nishihara

Takeshi Saito

Masumi Izuchi

Masaharu Terauchi

Hiroshi Tsutsu

Yoshinao Taketomi

Keizaburo Kuramasu

Hiroshi Satani

Hikaru Nishitani

Hideo Takasu

Takashi Terayama

Yoshiko Mino

Takayuki Miyoshi

Etsuyoshi Watarai

Shinpei Okajima

Takanori Kanehisa

Katsumi Adachi

Masakazu Takata

Noriyuki Sato

Kazushi Yamamoto

Yukihiro Morita

Satoshi Ikeda

Hirotaka Nanno

Junko Matsushita

Shinichiro Hashimoto

Toshihiko Torigoe

Masahiro Muro

Yoshihiko Hirohashi

Takuya Edamura

Takahiro Shimono

Seiji Mouri

Takao Nagumo

Tomohiro Ueno

Hirofumi Kawai

Ikuno Shimeno

Atsushi Tsujii

Yoichi Shintani

Masanori Miura

Kyohei Yoshino

Daiji Takeuchi

Jyun Sada

Yoshinori Yamada

Yohtaro Katagata

Takayuki Kanaseki

Natsuko Suginobe

Yusuke Imazaki

Yoshiko Iwata

Sho Miyamoto

Vitaly Kochin

Noriyuki Araki

Kiyoshi Sawada

Kayoko Hamada

Yukihiro Nakamura

Kouichi Shiozaki

Hidenobu Miyake

Toyoaki Naito

Seiko Itou

Youji Katou

Atushi Tujii

Megumi Nakamura

Akari Takaya

The present invention relates to a compound useful as a vaccine adjuvant for cancer vaccine, a preparation process thereof, a pharmaceutical composition comprising the compound, and use of the compound as a vaccine adjuvant for cancer vaccine.

Water soluble adjuvant and composition containing same

The present application relates to WT1 helper peptides consisting of an amino acid sequence of 9 to 30 amino acid residues including a sequence: KLSHL as part thereof, and combinations of a WT1 helper peptide and a conjugate of cancer antigen peptides.

WT1 helper peptides and combinations of WT1 helper peptide and conjugate of cancer antigen peptides

A compound represented by the formula (1): wherein Xand Yare each a single bond and the like, cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7-30 amino acid residues, Ris a hydrogen atom, a group represented by the formula (2): wherein Xand Yare each a single bond and the like, cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7-30 amino acid residues, or cancer antigen peptide C, and cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7-30 amino acid residues containing one cysteine residue, or a salt thereof, and the like.

WT1 antigen peptide conjugate vaccine

Provided is an instant noodles container lid that provides indication according to elapse of time from the start of boiling water process. An instant noodles container lid includes a surface member, an intermediate member, and a seal base member having a sealant layer in order, respectively, from one surface side. The surface member has a printed layer in an area other than a first area. The intermediate member includes a paper layer, a printed layer, a filling layer, and a wax layer in order, respectively, from the one surface side, and the wax layer is in a second area that covers the first area. A first half cut is formed from the surface member into the paper layer, in the first area. A second half cut is formed in the second area from the filling layer into the paper layer in a portion outside of the first area.

Instant noodles container lid

The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by Y-X-Z; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.

Tumor antigen peptide

An organic EL display panel including organic light emitting layers, each continuous in a column direction, in gaps between column banks. The organic light emitting layer in a gap end region extending in the column direction from a column direction end of the gap to a reference position a defined distance from the column direction end towards a display region and within a peripheral region has a volume greater than volumes of the organic light emitting layers in gap end regions extending in the column direction from column direction ends of the gaps to the reference position.

Organic EL display panel manufacturing method and organic EL display panel

The present invention provides a compound represented by the formula (1): wherein Xand Yare each a single bond or the like, cancer antigen peptide A is an MHC class I-restricted cancer antigen peptide, andRis a hydrogen atom; a group represented by the formula (2): wherein Xand Yare each a single bond or the like, and cancer antigen peptide B is different from the cancer antigen peptide A and is an MHC class I or II-restricted cancer antigen peptide; a group represented by the formula (3): wherein Xand Yare each a single bond or the like, and cancer antigen peptide C is an MHC class II-restricted cancer antigen peptide; or cancer antigen peptide D, wherein the cancer antigen peptide D is an MHC class I or II-restricted cancer antigen peptide containing one cysteine residue,or a salt thereof, for example.

Conjugate vaccine using trimming function of ERAP1

Forming functional layers including functional material in application regions by applying ink to the application regions then drying the ink, which contains the functional material, by causing nozzles to be scanned relative to the substrate along the row direction while, among the nozzles, only use-nozzles that are not selected as a defective nozzle eject the ink, the nozzles being arranged in the column direction over the substrate and including a nozzle selected in advance as a defective nozzle. Among the nozzles, when applying the ink, at least one reserve nozzle is present, a reserve nozzle being a nozzle that is not one of the use-nozzles, is not selected as the defective nozzle, passes over the application region, and does not eject the ink.

Method for manufacturing organic EL display panel

A flexible package including a package body including a first side-surface film and a second side-surface film sealed in a peripheral portion. The package body has sealed portions formed in side edge portions such that a non-sealed portion is formed in at least one of the sealed portions. The non-sealed portion has a gas injection portion containing a gas which has a specific heat at constant volume of 0.67 kJ/kg&#xb7;deg or higher at 0&#xb0; C. and 1 atm. The gas injection portion has a diameter of from 3 to 50 mm and is formed such that a repelling force is from 4 to 30 N at 23&#xb0; C. and 1 atm when an entire gas injection portion is nipped from both sides of the first and second side-surface films and squeezed until a nipped gas injection portion has a width equal to a half of the diameter of the gas injection portion.

Flexible package

A funnel component, and a packaging container using the funnel component are provided. A funnel component includes: a funnel portion having a diameter that is increased from a narrow opening side toward a wide opening side; a discharge portion that connects with an end portion on the narrow opening side; and a side wall portion that surrounds an opening portion, on the wide opening side, of the funnel portion, connects with the funnel portion, and is fitted into the container body. The funnel component is integrally formed by a sheet member including paper and sealant layer. A folded portion is formed, by the sheet member being folded back and welded over entire circumference, at an opening portion of the discharge portion. The packaging container is formed by the funnel component being fitted into a container body having an open end, a bottom portion, and a side wall.

Funnel component and packaging container using funnel component

The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.

Proteoglycan-containing material

A flexible package including a package body including a first side-surface film and a second side-surface film sealed in a peripheral portion such that a storage portion is formed in the package body. The package body has sealed portions formed in side edge portions such that a non-sealed portion is formed in at least one of the sealed portions. The non-sealed portion has a gas injection portion containing a gas which has a specific heat at constant volume of 0.67 kJ/kg&#xb7;deg or higher at 0&#xb0; C. and 1 atm. The gas injection portion has a diameter in a range of from 3 mm to 50 mm and is formed such that a repelling force is in a range of from 4 N to 30 N at 23&#xb0; C. and 1 atm when an entire gas injection portion is nipped from both sides of the first and second side-surface films and squeezed until a nipped gas injection portion has a width equal to a half of the diameter of the gas injection portion.

A locking member has a first surface, a first mounting opening and a second mounting opening. Each first mounting opening and second mounting opening is dimensioned to receive the shank portion of a corresponding rotatable member therethrough so that a bottom surface of a head portion of the rotatable member faces toward the first surface of the locking member. A first extending member extends elastically relative to the first surface, wherein the first extending member is disposed in close proximity to the first mounting opening. When the rotatable member is in a mounting position in the first mounting opening, the first extending member contacts the head portion of the rotatable member to inhibit the rotatable member from rotating in a first direction, and the first extending member deflects elastically when the rotatable member rotates in a second direction opposite the first direction.

Apparatus to assist mounting a bicycle component

Growing community of inventors

Osaka, Japan

Masashi Goto