Tanabe Seiyaku Company, Limited

Masaru Senuma

Mitsuyoshi Wagatsuma

Shigeru Nishimoto

Eisaku Yamato

Noboru Shigematsu

Nobuhiko Ishihara

Susumu Ohshiro

A stable trihydrate of (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-amino-3-(N-methylcarbamoyl)propionamido]-2-(p-hydrox yphenyl)acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-c arboxylic acid and process for preparing the same are disclosed.

Stable hydrate of penicillin derivative

Glyoxylic acid or a salt of glyoxylic, an ammonium salt of an organic or inorganic acid and a phenol compound of the formula: ##STR1## wherein n is an integer of one to three, are condensed together to prepare hydroxyphenylglycine compounds of the formula: ##STR2## wherein n is the same as defined above. The hydroxyphenylglycine compounds thus obtained are useful as intermediates in the synthesis of penicillins and cephalosporins.

Process for preparing a hydroxyphenylglycine compound

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Takatsuki, Japan

Masaru Senuma