Ajinomoto Co., Ltd.

Ajinomoto Co., Inc., Patent & Licensing Department

Masaru Otani

Kenzo Yokozeki

Hiroshi Shiragami

Naohiko Yasuda

Toshiya Tanabe

Yasuo Irie

Hideyuki Shirae

Shinichi Suzuki

Chiaki Sano

Toshio Kitahara

Michio Takahashi

Masami Kojima

Toru Sawasaki

Toru Shinohara

Isao Kusumoto

An amino acid and/or a peptide are orally administrated to a neonatal ruminant whose fermenting function of the rumen has not yet developed thereby effecting a significant increase in the accumulation of fat between the muscle fibers as well as increase of the fattening effect during the fattening period.

Method of fattening up a ruminant

Optically active tryptophan of high purity can be obtained in high yields from a tryptophan fermentation broth, using crystallization of optically active tryptophan hydrochloride in combination with concurrent neutralization crystallization. According to the present invention, optically active tryptophan from a tryptophan containing fermentation broth, is carried out by (a) removing cells from the fermentation broth, adding hydrochloric acid, or a mixture of hydrochloric acid and an inorganic salt which contains chloride ions, to the cell-free broth to effect crystallization, (b) separating optically active tryptophan hydrochloride, (c) dissolving the optically active tryptophan hydrochloride, and (d) subjecting the resulting solution and an alkali solution to concurrent neutralization crystallization, maintaining a pH of the crystallization solution in the range of from 3 to 8.

Method for recovering optically active tryptophan

A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for purifying 2',3'-dideoxynucleosides

A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for producing and purifying 2',3'-dideoxynucleosides, and

A method for separating leucine from a mixture of amino acids containing at least leucine and isoleucine, which comprises subjecting an aqueous solution of a mixture of amino acids to centrifugal force, and forcing by the application of pressure a water-saturated organic solvent immiscible with water to pass through the aqueous solution against the centrifugal force, to selectively extract leucine in said water-saturated organic solvent.

Method for the separation of leucine

A process for refining phenylalanine, in which a phenylalanine solution containing tyrosine as the main impurity and other impurities is contacted with a non-polar, highly porous synthetic adsorbent, adsorbing phenylalanine on the adsorbent selectively, and eluting and recovering the adsorbed phenylalanine, is disclosed.

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Tokyo, Japan

Masaru Otani