Toyo Jozo Kabushiki Kaisha

Toyo Jozo Company, Ltd.

Masaru Otani

Naoki Muto

Tadashiro Fujii

Shuzo Satoi

Tetsu Saito

Mitsuo Hayashi

Satoshi Yaginuma

Masatoshi Tsujino

Akira Kodama

Masaki Takada

Susumu Watanabe

Toshiharu Noda

Tetsuo Matsuda

Junzo Mizoguchi

Masaru Ono

Eisuke Munekata

Tadanori Morikawa

Hirose Yamauchi

Tosio Meguro

Seiji Katsumata

Shunpei Sakakibara

Shuichi Kitazawa

Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.

Antibiotic neplanocin A

Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.

Aminoglycoside antibiotic G-367-2

Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.

Neplanocin-B and -F

Aminoglycoside antibiotic G-367-1 believed to have the formulae ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.

Aminoglycoside antibiotic G-367-1 and method for the production thereof

A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.

Novel macrolide antibiotics and preparation thereof

An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Streptomyces.

Amino sugar compound

Antibiotics aculeacin-A.alpha., -A.gamma., -D.alpha. and -D.gamma. are active against yeasts and fungi. They are produced by culturing the microorganism Aspergillus aculeatus NRRL 11270 in a nutrient medium containing assimilable carbon and nitrogen sources.

Antibiotic aculeacin-A.alpha., -A.gamma., -D.alpha. and -D.gamma. and

A polypeptide having calcitonin activity of the formula ##EQU1## and the salts thereof with pharmaceutically acceptable acids.

EEL calcitonin

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Shizuoka, Japan

Masaru Otani