Shionogi Company Limited

Kurimoto, Ltd.

Masaru Ogata

Hiroshi Matsumoto

Katsuya Tawara

Yoshihachi Watanabe

Shiro Kida

Toshio Takahashi

Sumio Shimizu

Akihiko Sato

Hirohiko Sugimoto

Hisajiro Yukinaga

Tamio Fujiwara

Kosaburo Sato

Ken-ichi Sugita

Hideo Kano

Masami Eigyo

Katsumi Hirose

Teruya Okada

Takao Konishi

Kantaro Kaneko

Takashi Maeda

Takahiro Kataoka

Takayuki Hatta

A method and apparatus for producing a hydrogen adsorption alloy, the apparatus comprising a high speed ball mill in the form of a planetary ball mill mounted to a rotatable main shaft, wherein the planetary ball mill includes a plurality of mill pots each mounted for rotation on its own axis, a planetary gear disposed on the periphery of each mill pot, a fixed sun gear meshing with the planetary gears, and an atmosphere adjusting device connected to each mill pot. A drive rotates the main shaft causing each mill pot to revolve around the main shaft which results in the planetary gears traveling around the sun gear to rotate each mill pot on its own axis, the rotation of each mill pot being in the same direction as the rotation of the main shaft.

Apparatus for producing hydrogen adsorption alloy

A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.

Imidazole derivatives having anti-HIV activity

The compounds of the present invention inhibit HMG-CoA reductase, subsequently suppress the synthesis of cholesterol; and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.

Benzofuran derivative

A compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen, hydroxy, oxo, halogen, azido, amino, C.sub.1 -C.sub.3 alkylamino, or aminomethyl, in which said amino, C.sub.1 -C.sub.3 alkylamino and aminomethyl each is optionally substituted by one or two members selected from the group consisting of C.sub.1 -C.sub.3 alkyl and amino-protecting group; n is an integer of 1 to 3; p and q each is an integer of 0 to 3 with proviso that p+q=1 to 4 or acid-addition salts thereof, being useful materials for preparing side chains of antibacterial quinolonecarboxylic acids, cephalosporines, or other antibiotics.

Azabicycloalkanes

Novel pyridonecarboxylic acids of the formula: ##STR1## or the pharmaceutically acceptable salts thereof having a more potent and longer lasting antibacterial activities against gram-positive and gram-negative bacteria than known analogues, useful for antibacterial agents at an oral dose of 1-500 mg, preferably 50-100 mg per day to an adult.

Quinolone-carboxylic acids as antibacterial agents

A novel fungicidal compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl having 1 to 12 carbon atoms, ##STR2## R.sup.2 and R.sup.3 are hydrogen, bromine or methyl; R.sup.4 is alkenyl having 2 to 9 carbon atoms or alkynyl having 2 to 9 carbon atoms; m is an integer of 0 to 2; n is an integer of 0 to 1; p and q are independently integers of 1 to 8; Az is imidazolyl or 1,2,4-triazolyl, Q is --CO--, --O-- or --CO--NR.sup.5 --; R.sup.5 is hydrogen or methyl, Y is hydrogen, fluorine, chlorine or phenyl; and Z is hydrogen, fluorine, chlorine or methyl, provided that, when Z is hydrogen or chlorine, n is 1, or its salt. A process for producing the compound (I) and a fungicide containing the compound (i) are also disclosed.

Fungicidal azole derivatives

A compound of the formula: ##STR1## (wherein Az is imidazolyl or triazolyl;

Azole type dioxolane derivatives

Novel sulfonamide benzamides which have potent antiviral and anti-coccidial activities with low toxicity and compositions containing them used in prophylaxis or treatment of viral infectious diseases or coccidiosis are provided.

Sulfonamido-benzamide derivatives

Novel benzylimidazole derivatives of the formula: ##STR1## wherein X is halogen, nitro, alkyl, alkoxy, or halobenzyloxy;

Agricultural composition and method utilizing 1-benzylimidazole

Benzylimidazole derivatives of the formula: ##STR1## wherein X is halogen, nitro, alkyl, alkoxy, or halobenzyloxy;

Bis-imidazolyl-bis-phenylmethane derivatives and their use as fungicides

1-Benzylimidazole derivatives useful as antimycotic agents having superior activity and as agricultural bactericides effective against various plant pathogenic bacteria and soil bacteria, derived from hydroxyphenylvinylimidazoles.

1-Benzylimidazole derivatives

3-Sulfonamido-benzophenonimine derivatives useful for prophylactically or therapeutically treating patients suffering from viral infections are provided from 3-sulfonamido-benzophenones.

3-Sulfonamido-benzophenonimine derivatives useful for treating virus

Benzylazole derivatives being useful as antiarrhythmic agent are obtained by reacting the corresponding 2,3-epoxypropyloxybenzylazole with a primary or secondary amine.

Antiarrhytmic benzylimidazole

Meta-sulfonamido-benzamide derivatives of the formula: ##STR1## [wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group;

Growing community of inventors

Hyogo, Japan

Masaru Ogata