Toyo Boseki Kabushiki Kaisha

National Institute of Advanced Industrial Science and Technology

Toyobo Co., Ltd.

Daito Kasei Kogyo Co., Ltd.

Masaru Kitagawa

Atsushi Sogabe

Michiko Suzuki

Yutaka Tokiwa

Yoshihisa Kasukabe

Shuhei Yamamoto

Tomotake Morita

Dai Kitamoto

Shusaku Yanagidani

Hiroaki Kitazawa

Makoto Ashiuchi

Tomohiro Imura

Takumi Tanaka

Tokuma Fukuoka

Takao Raku

Kenji Nishimoto

Kenji Yoshino

Tetsuzo Totani

Hiromi Shimakawa

To provide cosmetic pigments that are human-body friendly with good skin adhesion and that provide good feeling, their production method, and cosmetics containing such cosmetic pigments which provide fresh and enriched feeling accordingly. Pigment surfaces are coated with mannosylerythritol lipid, which is glucolipids, consisting of mannose, sugar alcohol and a fatty acid as shown in the general expression (1) below: (Note: In the general expression, Rand Rdenote aliphatic acyl group with carbon numbers 6 through 20, which can be either same or different. Rand Rdenote hydrogen or acetyl group, which can be either same or different. n denotes an integer in the range of 2 to 4.)

Cosmetic pigments, their production method, and cosmetics containing the cosmetic pigments

There are provided a microorganism characterized by producing poly-&#x3b3;-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-&#x3b3;-L-glutamate having large molecular weight by using the microorganism, and poly-&#x3b3;-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.

&#x3b3;-L-PGA producing microorganism, method of producing &#x3b3;-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism

The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-&#x3b2;-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof

Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.

Tyrosinase activity controlling agent, process for producing the same and external preparation containing the same

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Osaka, Japan

Masaru Kitagawa