National Institutes of Health, a Component of the US Dept. of Health & Human Services

Masaru Kawamura

Warren Jaye Leonard

John J O'Shea

Daniel W McVicar

James A Johnston

Sarah M Russell

An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

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Rockville, MD, United States of America

Masaru Kawamura