Basilea Pharmaceutica Ag

Chugai Seiyaku Kabushiki Kaisha

Basilea Pharmaceutica Ag, a Swiss Company

Masao Tsukazaki

Nobuo Shimma

Isao Umeda

Jun Ohwada

Tadakatsu Hayase

Hiroshi Fukuda

Nobuhiro Oikawa

Masahiro Sakaitani

Eisaku Mizuguchi

Takeshi Murata

Satoshi Niizuma

Hitomi Suda

Yoshiaki Isshiki

Shigeyasu Ichihara

Toshikazu Yamazaki

Toshiya Sakai

Pingli Liu

This invention relates to novel processes for the preparation of compounds of the formula [1], wherein R1, R2, R3 and R4 are as defined in the claims and description as well as pharmaceutically acceptable salts thereof. The compounds of the formula [1] are hexacyclic compounds having potent anti-tumor activity. 

Process for the preparation of hexacyclic compounds

N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

N-substituted carbamoyloxyalkyl-azolium derivatives

N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.

N-phenyl substituted carbamoyloxyalkyl-azolium derivatives

Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives

The present invention relates to hexacyclic compound of the formula [1], wherein Z, Rand Rare as identified therein, and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of cell proliferative disorders.

Hexacyclic compounds and their therapeutic use

Hexacyclic compounds

Azoles for treatment of fungal infections

Growing community of inventors

Fujisawa, Japan

Masao Tsukazaki