Yoshitomi Pharmaceutical Industries, Ltd.

Masao Ohyama

Kaoru Kobayashi

Yahiro Uemura

Shinobu Kuwae

Tomoshi Ohya

Toyoo Ohda

A production method of a heterologous protein, comprising culturing a heterologous protein-producing host prepared by gene manipulation in a medium containing a fatty acid or a salt thereof, and a surfactant and harvesting the heterologous protein from the culture. The production amount of the heterologous protein produced by a heterologous protein-producing host can be increased. Moreover, since decomposition of the heterologous protein by an enzyme derived from the host can be inhibited, enabling large scale production of a heterologous protein.

Growing community of inventors

Hirakata, Japan

Masao Ohyama