Ono Pharmaceutical Co., Ltd.

Ono Pharmaceuticals Co., Ltd.

Masao Naka

Kaoru Kobayashi

Naoyuki Taniguchi

Tadamitsu Kishimoto

Jun Takeuchi

Takuya Seko

Shinya Takahashi

Mitoshi Konno

Mikio Konishi

Katsuhito Sakaki

Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient

Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.

2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient

Condensed piperidine compound

A compound represented by formula (I): ##STR1## wherein all symbols are defined in the specification, or an acid addition salt thereof or a hydrate thereof; a process for preparing the same; and a nitrogen monoxide synthase inhibitor comprising the same as an active ingredient.

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Mishima-gun, Japan

Masao Naka