Takeda Pharmaceutical Company Limited

Masao Nagao

Naoki Asakawa

Masami Kusaka

Jun Sato

Nobuyuki Takechi

Yoshihiro Omachi

Yasuhiro Hiraishi

Takayuki Doen

Shigehiro Asano

The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojectionserected on one support sheet, each microprojectionhaving a drug layersoluble in vivo at its top part and having an intermediate layerunder the drug layer, the intermediate layercontaining a polymeric substance for adhesion of the drug layerto the support sheet, the drug layerat the top part of the microprojectioncontaining a single drug, the microprojectionsholding difference types of drugs being arranged together on the support sheet

Microneedle patch

An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.

Injections

The present invention relates to a pharmaceutical composition containing a cycloalkene compound, a salt thereof or a prodrug thereof, and a nonionic surfactant and/or a cyclodextrin derivative readily soluble in water, and a method for improving solubility, stability or coloring property of the compound, a salt thereof or a prodrug thereof.

Pharmaceutical composition

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Kashiba, Japan

Masao Nagao