Nippon Shinyaku Company, Ltd.

Masao Murase

Hiroshi Enomoto

Yoshiaki Aoyagi

Shoichi Chokai

Kichiro Inoue

Tadatoshi Nomura

Shigeaki Maruo

Tatsuhiko Kono

Masahiro Adachi

Ichiro Shirahase

Yukio Fujita

A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is S or O;

Quinoline substituted oxomethyl or thioxomethyl glycine derivatives and

A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.

Glycine derivatives

4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

4-quinolone derivatives having anti-inflammatory, anti-allergic,

3-methylflavone derivatives which are useful in the treatment of allergies, asthma and inflammation.

Methylflavone-8-carboxylates

4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

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Kusatsu, Japan

Masao Murase