Agency of Industrial Science and Technology

Ministry of International Trade & Industry

Other

Japan Science and Technology Corporation

Research Development Corporation of Japan

Nanocarrier Co., Ltd.

Toda Kogyo Corporation

Japan As Represented by Director General of Agency of Industrial Science

K. K. Vayu

Kazunori Kataoka

Masao Kato

Yukio Nagasaki

Hachiro Nakanishi

Hiro Matsuda

Teruo Okano

Shuji Okada

Yasuhisa Sakurai

Masayuki Yokoyama

Kazuo Nakayama

Yoshio Tanaka

Michihiro Iijima

Hiroo Matsuda

Teruo Nakamura

Tsutomu Takezawa

Nobuyuki Ohsako

Atsushi Harada

Norihisa Kobayashi

Nanao Horiishi

Eishun Tsuchida

Shinji Yamada

Minoru Ohsugi

Shigeru Takaragi

Takashi Fukuda

Teiji Tsuruta

Ken Suzuki

Carmen Scholz

Setsuko Furuya

Shunji Ohnishi

Yuji Orihashi

Hotaka Ito

Xuan-Ming Duan

Tatsumi Kimura

Yasuo Sato

Daisuke Wakebayashi

Takahisa Hayashida

Takahito Kutsuna

The present invention provides a polymer obtained by polymerizing a mixture composed of a methacrylic ester monomer having an electron-donating group bonded to a specific site of its ester-forming residue (its alcohol moiety) and optionally a lactone or lactide, while using an alkali metal alcoholate as a polymerization initiator. Moreover, it also provides a process for preparing the polymer and polymer micelles formed from the polymer. Since the polymer has a functional group corresponding to the polymerization initiator and the aforesaid electron-donating groups (functional groups), it can perform a great variety of functions by taking advantage of these functional groups.

Methacrylic polymer having a terminal functional group and composition thereof

Polyoxyethylene derivatives having optionally protected amino group at one end and process for producing the same

Modified polymers containing a poly(2-hydroxyethyl(meth)acrylate) chain as the hydrophilic polymer segment in which a hydrophobic polymer chain or a lipid residue of a sterol is bound to either end of the poly(2-hydroxyethyl(meth)acrylate) chain through a covalent bond or in which the poly(2-hydroxyethyl(meth)acrylate) chain is grafted onto the backbone chain at either end thereof. These modified polymers are excellent in compatibility with liquid or a living body, thus being advantageously usable particularly in medical fields.

Modified polymers containing poly(2-hydroxyethyl(meth)acrylate segment in the molecule

Antitumor agent which comprises as the principal agent a mixture of organic compounds having amino group and silyl group (reffered to as silamines) and represented by structural formulae with Adriamycin. Use of silamines in the form of a mixture with Adriamycin, which is an anti-cancer agent showing a potent effect but having extremely serious side effects, makes it possible to highly potentiate the anti-cancer properties of Adriamycin. As a result, the dose of Adriamycincan be reduced and thus its side effects can be relatively relieved as compared with the case where it is used alone.

Antitumor agents comprising as the principal compounds containing silicon and nitrogen

This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,

Polyoxyethylene having a sugar on one end and a different functional

Disclosed is a novel aromatic ester compound represented by the general formula ##STR1## in which Pn is a 1,4-phenylene group, R.sup.1 is an alkyl group having 1 to 4 carbon atoms, R.sup.2 is a group selected from the group consisting of perfluoroalkyl groups having 1 to 4 carbon atoms, cyano group, nitro group, 2,2-dicyanoethenyl group and methylsulfonyl group and the subscript n is a number of 2, 3 or 4. These aromatic ester compounds are useful as a second-order non-linear optical material in the ultraviolet wavelength range so that a resin film containing the compound has a good second-order non-linear optical coefficient d.sub.33 of 2-4.times.10.sup.-9 esu.

Aromatic ester compound and second-order non-linear optical material

Polyethylene oxides having saccharide residue at one end and different

Block polymer having functional groups at both ends

Heterotelechelic block copolymers and process for producing the same

Antitumor agents comprising as the principal compounds containing

The present invention relates to a bifunctional polyether having groups different from each other at both ends, with a polymerization degree of 5 to 10000 and consisting of repeating units each represented by the following formula (I): ##STR1## (wherein R.sub.1, represents a hydrogen atom, halogen atom, or a lower alkyl group optionally substituted by a halogen atom, and R.sub.1 in each repeating unit may be the same or different), as well as to a process for the preparation thereof and a polymerization initiator therefor. The process of production and polymerization initiator of the present invention enable 100% introduction of a primary amino group into one of the ends of polyether.

Polyether having heterofunctional groups at both ends, process for the

Disclosed herein are polydiphenyldiacetylenes having the following repeating unit (III): ##STR1## (wherein R.sup.1 denotes a hydrogen atom or a methoxy group; R.sup.2 denotes a hydrogen atom, a methoxy group or a methylamino group; R.sup.3 denotes a hydrogen atom or a trifluoromethyl group; and R.sup.4 denotes a hydrogen atom or a trifluoromethyl group; provided that R.sup.1 is not a hydrogen atom when R.sup.2 is hydrogen atom, and R.sup.3 is not a hydrogen atom when R.sup.4 is hydrogen atom).

Polydiphenyldiacetylenes

A polymeric nonlinear optical material is produced by mixing a polyelectrolyte solution with an ionic pigment solution thereby obtaining a solution containing a composite of said polyelectrolyte and said ionic pigment, and separating said composite from said solution.

Method for production of polymeric nonlinear optical material

A thickness determination method for organic films comprises the steps of: irradiating an organic film to be measured with x-rays at a certain angle of incidence, finding an angle of reflection at which the x-ray intensity reaches a peak, and finding the thickness of the film from the angle of this peak.

Method using x-rays to determine thickness of organic films

Growing community of inventors

Tsukuba, Japan

Masao Kato