Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Mercian Corporation

Masao Iwata

Kiyoshi Okamoto

Mitsuo Nagai

Yoshihiko Kotake

Jun Niijima

Takashi Nakashima

Satoshi Yamamoto

Toshio Tsuchida

Masashi Yoshida

Kazuyuki Dobashi

Yoshiharu Mizui

Toshimitsu Uenaka

Tomohiro Sameshima

Naoto Kawamura

Takao Yamori

Masanori Fujita

Susumu Takeda

Naoki Asai

Motoko Matsufuji

Takashi Sakai

Tomonari Yamada

Akifumi Okuda

Keisuke Komeda

Kumiko Kishi

Koji Norihisa

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it. 

Bioactive substance

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it

Physiologically active substances

Growing community of inventors

Ibaraki, Japan

Masao Iwata