Tanabe Seiyaku Company, Limited

Masao Hoshiyama

Taku Nagao

Nobuo Ito

Hiromichi Nakajima

Muneyoshi Ikezaki

Yasushi Okazaki

Yashushi Okazaki

A compound of the formula: ##STR1## wherein R is lower alkyl, may be prepared, for example, by reducing a compound of the formula: ##STR2## wherein R is same as above. Other methods for preparing the compound [I] are also disclosed. The compound [I] and a pharmaceutically acceptable acid addition salt thereof are useful as anti-diabetic agents.

Novel benzylalcohol derivatives and processes for preparing the same

A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.

Novel benzylalcohol derivatives as antidiabetics and cardiotonics

Benzylalcohol amine derivatives

A compound of the formula: ##SPC1## Wherein Ring A' is dibenzyloxyphenyl and Y is carbonyl or hydroxymethylene, is subjected to catalytic hydrogenation. A compound of the formula: ##SPC2## Wherein Ring A is dihydroxyphenyl, is produced. The product is useful as a cardiotonic agent. It is also characterized by the high potency ratio of adrenergic .beta..sub.1 -receptor stimulating activity to adrenergic .beta..sub.2 -receptor stimulating activity.

.alpha.-(3,4-Dimethoxyphenethylaminomethyl)-3,4 or

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Masao Hoshiyama