Sumitomo Pharmaceuticals Company Limited

Sumitomo Chemical Company, Limited

Masao Enomoto

Atsuyuki Kojima

Yuzuru Sanemitsu

Masato Mizutani

Shigeaki Morooka

Yoshihiro Komuro

Makoto Sunagawa

Shunji Aono

You Tanabe

Keiichi Ono

Toshio Atsumi

Akira Sasaki

Haruki Matsumura

Masami Muraoka

Takaaki Inoue

Hiroaki Masumori

Koshiro Goda

Youichi Hara

Naruhito Masai

Nobuyuki Hara

Thiazolidin-4-one derivative represented by the following general formula (I) and acid addition salts thereof ##STR1## wherein; R.sup.1 and R.sup.2 are the same or different and denote each

Thiazolidin-4-one derivatives and acid addition salts thereof useful for

A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.

Certain pyridyl-thiazolidin-4-one having anti-ulcer activity

Thiazolidin-4-one derivative represented by the folowing general formula (I) and acid addition salts thereof ##STR1## wherein; R.sup.1 and R.sup.2 are the same or different and denote each

Thiazolidin-4-one derivatives useful for treating diseases caused by

A novel 2-pyridylthiazolidin-4-one derivative represented by the general formula ##STR1## wherein Ar denotes an aryl group unsubstituted or substituted with a halogen atom or with a lower alkoxy group; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl) amino, hydroxyl or aryl group, or denotes an aryl group substituted with a lower alkoxy group; and Py denotes a pyridyl group, and the acid addition salt thereof, which have an excellent platelet activating factor antagonsm.

Novel thiazolidin-4-one derivatives and acid addition salts therof

Novel .beta.-lactam compounds classified into penem compounds, a process for preparing the same and use of such .beta.-lactam compounds are disclosed. These .beta.-lactam compounds exhibit excellent antimicrobial activities useful as pharmaceuticals or they are important intermediates for the synthesis of compounds having antimicrobial activities.

Antibacterial .beta.-lactam compounds

.beta.-Lactam compounds which are useful as intermediates for the production of carbapenem or penem derivatives and a process for producing the same. The process comprises reacting a Schiff base with diketene in the presence of an imidazole, reducing the acetyl group of the resulting N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester, and removing the protecting group for a carboxyl group from the resulting 3-(1-hydroxyethyl)-2-azetidinone-4-carboxylic acid derivative.

4-Carboxy azetidinone compounds and production thereof from diketene and

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Osaka, Japan

Masao Enomoto