Tanabe Seiyaku Company, Limited

Masanori Sato

Muneyoshi Ikezaki

Norihide Umino

Taku Nagao

Katsuo Ikezawa

Kunihiko Irie

Tokuro Ohishi

A compound of the formula: ##STR1## wherein R is alkanoyl of one to 20 carbon atoms, benzoyl or lower alkyl-benzoyl, and processes for preparation thereof are disclosed. Said compound (I) and a pharmaceutically acceptable acid addition salt thereof are useful as a cardiotonic agent.

Novel benzylalcohol derivatives and processes for preparing same

A novel 5,7-dihydroxytetrahydroisoquinoline derivative having the formula: ##STR1## wherein R is trimethoxyphenyl, is prepared either by hydrolysis of a compound having the formula: ##STR2## wherein R.sup.1 is an organic acyl group and R is same as above, or by catalytic hydrogenation of a compound having the formula: ##STR3## wherein R.sup.3 is hydrogen or benzyl and R is same as above. The 5,7-dihydroxytetrahydroisoquinoline derivative (I) or a pharmaceutically acceptable acid addition salt thereof is useful as a bronchodilator.

5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolines and

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Kuki, Japan

Masanori Sato