Banyu Pharmaceutical Co. Ltd

Masanori Okanishi

Hiroyuki Suda

Akira Okura

Kenji Kawamura

Katuhisa Kojiri

Daisuke Uemura

Seiichi Tanaka

Katsuhisa Kojiri

Kohtaro Funaishi

Hajime Suzuki

Shigeru Nakajima

Akira Okuyama

Kyozo Naito

Toshihiro Yamamoto

Yoshimasa Hirata

Nobuo Kanbayashi

Koutaro Funaishi

Takeshi Watanabe

This invention relates to 12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione derivatives represented by the following general formula, pharmaceutically acceptable salts thereof, a method for preparation thereof and a use thereof: ##STR1## [wherein R.sup.1 denotes a monosaccharide group having 5 to 7 carbon atoms, and the hydroxyl groups of this monosaccharide group can be replaced by the same or different 1 to 3 groups selected from the group consisting of a hydrogen atom, lower alkyl group, lower alkylcarbonyloxy group and lower alkoxy group.]

Method for preparing antitumor substance BE-13793C derivatives

Antitumor substance BE-13793C derivatives

The present invention relates to new stromelysin (human)-inhibitors, i.e., physiologically active substances BE-16627 represented by the general formula: ##STR1## wherein R represents a hydrogen atom or a methyl group, or pharmaceutically acceptable salts thereof, a process for the production and use thereof, and a microorganism producing the substance BE-16627.

Physiologically active substance BE-16627

A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism Streptoverticillium FERM P-10489, capable of producing the novel substance are disclosed.

Streptoverticillium ferm P-10489 which produces antitumor agent BE-13793C

A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism capable of producing the novel substance are disclosed.

Antitumor substance BE-13793C

An antitumor substance BE-12406 or a pharmaceutically acceptable salt thereof, which is represented by the general formula ##STR1## and a method of producing the novel substance.

Antitumor substance BE-12406

The present invention provides glycookadaic acid or salts thereof, processes for the preparation of such compounds, methods for treating and preventing cachexia and a side effect caused by TNF, and pharmaceutical compositions comprising such compounds as active components for treating and preventing cachexia and a side effect caused by TNF.

Glycookadaic acid, preparation thereof and use thereof

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Tokyo, Japan

Masanori Okanishi