Fujimori Kogyo Co., Ltd.

Baxter Travenol Laboratories, Inc.

Meiji Milk Products Company, Limited

Fujimoro Kogyo Co Ltd

Johnson & Johnson Medical Kabushiki Kaisha

Softex Co., Ltd.

Masanori Nagata

Shigeki Imano

Toyoaki Suzuki

Kazuya Hosokawa

Tsugio Kaneoka

Leonard F Czuba

Juuro Aoyagi

R Daniel Webster

Toshitaka Kobayashi

William D Johnston

Hideaki Honma

Kiyotoshi Asada

Kenichi Kakimoto

Hitoshi Matumoto

Hideki Nishiyama

Teiko Sutoh

Reiko Kato

Makoto Sagara

Yasuhiko Hori

A method for the refinement of a thrombin substrate, characterized by comprising therein a step of affinity chromatography formed by using an affinity adsorbent having as a ligand a thrombin or thrombin analogue deprived of nucleophilicity (activity) without causing stereostructure to the linkage with a substrate is disclosed.

Method for purifying thrombin substrate and/or inhibitors or method for eliminating the same

This invention provides a sheet which has a chemical indicator, in particular, a composition layer for use as an indicator in hydrogen peroxide plasma sterilization, and further provides a packaging bag for said sterilization with use of such an indicator. Said composition layer comprises both a dye which can change color when contacted with hydrogen peroxide vapor or plasma derived from hydrogen peroxide, and a certain organic amine compound.

Chemical indicator sheets and packaging bags for sterilization made with the use of the same

A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. The method comprises

Method for synthesis of anhydrothrombin

A method for the production of a microsphere without use of a dispersion stabilizer is disclosed which permits the microsphere to be produced in the form of discrete particles readily treatable for purification. The method which produces this microsphere comprises the steps of dissolving in an organic solvent such as an alcohol a monomer mixture including an ethylenically unsaturated amide and 10 to 70% by weight, based on 100% by weight of said monomer mixture, of a cross-linking agent thereby preparing a mixed solution, keeping said mixed solution at a temperature in the range of from 30.degree. to 95.degree. C., and adding thereto at least one initiator selected from the group consisting of peroxide type initiators and azo type initiators in an amount such as to be contained therein at a final concentration in the range of from 1.times.10.sup.-5 to 8.times.10.sup.-2 mol/liter thereby inducing polymerization of said monomer mixture. The microsphere consequently obtained can be used as one kind of a substrate most suitable for the preparation of an affinity adsorbent serving ideally as a filler for use in affinity chromatography.

Microsphere and method for production thereof

Method and apparatus for enabling fluid material contained in a package to be examined in a non-destructive manner to see whether there is any unacceptable alteration in the material. This examination is accomplished by shaking the package so that the package and its contents vibrate at the natural resonance frequency thereof, exposing the package to an irradiation of ultra-soft X-ray beams while the package is vibrating at the resonant frequency, either immediately after the package contents begin to be agitated by shaking or immediately after the vibration is stopped and it ceases to be agitated, detecting the strength of X-rays transmitted through the package and its contents, coverting the transmitted X-rays to a corresponding analog signal, and determining any alteration by comparing the analog signal against the refernece signal previously obtained in the same manner as described above for a like package with unaltered contents.

Method of and apparatus for examining objects in containers in

The invention provides an ultrasonic method of inspecting contents (fluid food, for instance) of a package by disposing an ultrasonic transmitter-receiver system on at least one side of the package and evaluating the occurrence or degree of degradation of the contents on the basis of output data from the system. The invention also provides an ultrasonic apparatus for inspecting contents of a package which comprises a shaking device for feeding and shaking the package, an ultrasonic device disposed independently and downstream of the shaking device, and a guide device for feeding the package downstream of the shaking device to the ultrasonic device and further downstream.

Ultrasonic method of inspecting contents of a package and apparatus

There is disclosed an apparatus and method for inspecting the contents, such as food, of a package, particularly a light-opaque package, for degradation or the degree of degradation by means of ultra-soft X-rays. The inspection apparatus generally comprises a shaking unit for shaking the package and a main inspecting unit disposed downstream and independently of the shaking unit. The assessment of degradation of the degree of degradation can be made according to the state of dispersion, after shaking, of the package head space in the X-ray image information. The method and apparatus eliminate losses arising from destructive inspection.

Method and apparatus for the inspection of contents of packaged products

A film laminate for flexible containers capable of containing a product to be maintained and removed under sterile conditions. The film laminate having an outside layer of linear low density polyethylene, a gas barrier layer, a core layer of polyamide, and an inside layer of linear low density polyethylene. The layers being bonded together by a polyurethane adhesive.

Film laminate with gas barrier for sterile flexible containers

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Tokyo, Japan

Masanori Nagata