Teijin Limited

Fujisawa Pharmaceutical Company, Ltd.

Masanori Fukushima

Satoshi Sugiura

Ryoji Noyori

Seizi Kurozumi

Hiroyuki Kikuchi

Toshitaka Manda

Yasuji Yamada

Iwao Shimizu

Yasumasa Tsukitani

Osamu Hirai

Novel 5-alkylidene-4-substituted-2-cyclopentenones and 5-(1-hydroxy-aliphatic hydrocarbon)-4-substituted-2-cyclopentenones. These novel cyclopentenones and 5-alkylidene-3-hydroxy-4-substituted cyclopentanones have a pharmaceutical activity for treatment of tumors.

Novel 5-membered cyclic compounds, process for production thereof, and

Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

Clavulone derivatives, process for preparing the same, and use of said

Growing community of inventors

Nagoya, Japan

Masanori Fukushima