Morishita Jintan Co., Ltd.

Osaka Prefecture University Public Corporation

Ipe Inc.

Masanori Asada

Ryosei Kamaguchi

Hideki Sunohara

Toshiro Shirakawa

Yuzo Kawahara

Yumi Hatano

Tadashi Kanaya

Youichi Matsuura

Tetsuya Ogawa

Takane Katayama

Shinichi Kitamura

Masaaki Nakatsuji

Yasunobu Kano

Mamiko Kohno

Tomoe Yoshino

Kosuke Shimamoto

Jun Wada

Sakura Yamamoto

Masayuki Yoshikawa

Michiko Taniguchi

Norihisa Nishida

Kiyofumi Ninomiya

Asako Okamoto

Tetsuo Takata

Masato Kawabata

Yumi Uehara

Mikiko Shimada

The present invention provides a method for inhibiting blood phosphorus level elevation, including administering to a patient in need thereof a composition comprising a lactic acid bacterium as an active ingredient. The method may further include encapsulating the composition comprising a lactic acid bacterium in a capsule. The inhibitor for blood phosphorus level elevation of the present invention is highly safe, is readily administrable, and can sufficiently inhibit a blood phosphorus level elevation.

Method for inhibition of blood phosphorus level elevation

Artificial seeds formed of a seamless soft capsule are provided herein. The artificial seed contains a meristematic plant cell or tissue. The artificial seed has a structure of three or more layers containing an innermost layer, an inner layer covering the innermost layer, and an outer layer covering the inner layer. The innermost layer can contain an aqueous liquid, the inner layer can be formed by an inner membrane containing hardened oil, and the outer layer can be formed of a biodegradable outer membrane.

Capsules containing vital cells or tissues

The present invention provides an oral vaccine against a bacterial infectious disease (e.g., typhoid fever, cholera, or dysentery). The oral vaccine of the present invention is a capsule formulation in which a transformed microorganism that expresses a flagellin antigen protein or that secretes a flagellin antigen protein out of the cell of the microorganism is encapsulated with an acid-resistant membrane. Examples of the microorganism include intestinal bacteria belonging to the genus, the genus, the genus, and the like. The form of the capsule formulation may be any one of a seamless capsule formulation, a soft capsule formulation, and a hard capsule formulation.

Oral vaccine

The present invention provides a fat metabolism improving agent comprising rose hips or an extract therefrom as an active ingredient. This fat metabolism improving agent is very safe and has a superior body weight reducing effect.

Method of improving fat metabolism

According to the present invention, there is provided a means of expressing and displaying a protein on the cell surface of a. In the gene for expressing a protein on the surface of aof the present invention, a gene coding for a-derived GNB/LNB substrate-binding membrane protein and a gene coding for the target protein or peptide are linked in this order from the 5' end side. Thus, atransformed by introducing the gene for expressing a protein on the surface of aof the present invention expresses the target protein or peptide on the surface thereof. When the target protein or peptide is an antigen protein or an antigen peptide, the transformedof the present invention is useful as an oral vaccine.

Gene expressing a bifidobacterium surface-presented fusion protein

A polysaccharide comprising galactose, glucose, rhamnose, and pyruvic acid as constituents, wherein the galactose, glucose, and rhamnose are contained in a molar ratio of 4:2:1, and the pyruvic acid is contained in an amount of 4 to 7 wt %. The polysaccharide can be obtained by culturingJBL05 (NITE BP-82) under anaerobic conditions.

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Capsules which contain vital cells or tissues as the contents and in which these cells or tissues can be grown. Since these cells or tissues can be grown in the capsules, an extremely high cell density can be achieved. By using these capsules, foods having an excellent effect of ameliorating intestinal disorders, etc. can be provided. Moreover, it is possible to provide artificial seeds showing an excellent storage stability and a high germination ratio which comprise seamless soft capsules consisting of an innermost layer containing indefinite embryo, indefinite shoots, multiple shoots, shoot apexes, growing points, protocorm-like bodies, indefinite roots, hairy roots, etc., an inner coating layer comprising a hardened oil and an outer coating layer made of a biodegradable film comprising gelatin, polysaccharides, etc.

Growing community of inventors

Osaka, Japan

Masanori Asada