Wakamoto Pharmaceutical Co., Ltd.

Masanobu Takeuchi

Hidekazu Suzuki

Hiroki Maruyama

Touru Oguma

Hiroe Suzuki

Makoto Maeda

Toshie Takahashi

Satoshi Yamazaki

Takahiro Wada

Masayoshi Goto

Yoshikazu Naito

Kenji Naito

Yoshiaki Saito

Daisuke Morizono

Keiko Naito

Miyako Sasaki

Masanobu Kirita

Keiko Naitou

Miyako Fukushima

The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent. The present invention relates to an antibacterial aqueous pharmaceutical composition

Aqueous pharmaceutical compositions

The present invention provides an ophthalmic aqueous pharmaceutical preparation, which is excellent in anti-inflammatory effect, which is less stimulative and which has high safety and excellent storage stability. The ophthalmic aqueous pharmaceutical preparation comprises meloxicam and trometamol.

Ophthalmic aqueous pharmaceutical preparation

An O/W emulsion composition comprising fluorometholone or clobetasone butyrate, a phospholipid, an oil, a nonionic water-soluble cellulose derivative, and water. The O/W composition has advantages that fluorometholone or clobetasone butyrate contained therein is highly bioavailable and that the solubility of fluorometholone or clobetasone butyrate and the concentration thereof present in the composition can be kept stable. Thus, this composition is usable for the treatment of various inflammatory diseases by the generalized or local administration thereof. It provides a drug which shows an anti-inflammatory activity equal or higher than that of commercially available eye drops comprising a suspension of such an active ingredient even when it is applied in a smaller dose than that of commercially available one and further provides a drug having excellent storability, which reduces apprehension of systemic side effects of fluorometholone or clobetasone butyrate when it is applied to the eyes.

O/W emulsion composition

Anti-inflammatory eye drop

Lyophilized pharmaceutical preparations capable of providing aqueous

Aqueous drug composition having property of reversible thermosetting

Growing community of inventors

Tokyo, Japan

Masanobu Takeuchi