Nippon Kayaku Kabushiki Kaisha

Other

Enplas Corporation

Hitachi Plant Technologies, Ltd.

Sakurai, Yasuhisa

Masanobu Suzuki

Katsutoshi Takahashi

Hisao Ekimoto

Takeshi Nakanishi

Akio Fujii

Yoshishige Endo

Akira Masuda

Noriyuki Kawahara

Shigeto Fukushima

Tokuji Nakatani

Keizou Ishikawa

Yuzuru Ito

Kazuhisa Shimizu

Hidekazu Tsudome

Osamu Kogawa

Ryuji Uehara

Takao Izawa

Yukio Irie

Masato Suwa

Fumiko Kobayashi

Miyoji Hanaoka

Naofumi Otsuki

Michimasa Aono

Megumi Machida

Tomoko Akutsu

Kenichiro Miyamoto

A joint to be attached to a port of a micro fluidic element, has an outer peripheral surface of truncated subulate shape at a front end portion of the joint to form a front surface as a top of the truncated subulate shape, and a cuneiform space in an inside of the joint at the front end portion of the joint, the joint is made of an elastomer, and the cuneiform space includes a front end overlapping the front surface as seen in a direction along which a tube is guided by the cuneiform space when the tube is inserted into the joint so that the tube is enabled to penetrate the front surface through the front end.

Micro fluidic device and joint therefor

A process for purification which permits satisfactory removal of impurities from a block copolymer consisting essentially of polyethylene glycols and poly(acidic amino acid) and is suitable for the production of a polymeric carrier having a pharmaceutically acceptable purity; a process for producing such a polymeric carrier; a block copolymer reduced in impurity content; a polymeric carrier as described above; pharmaceutical preparations in polymeric form, produced by the use of the carrier; and a method of subjecting polyethylene glycols and poly(acidic amino acids)&#x2014;which are impurities contained in the block copolymer&#x2014;to treatment with either an ion-exchange resin or a partition/absorption resin and then determining the quantities of them with a gel filtration column.

Block copolymer reduced in impurity content, polymeric carrier, pharmaceutical preparations in polymeric form and process for the preparation of the same

A novel phenanthridinium derivative represented by general formula (A):

Phenanthridinium derivatives

The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.

Process for preparing benzo�c!phenanthridinium derivatives, novel

This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):

Selenium oxy chloride-pyridine or bipyridine complexes

Growing community of inventors

Saitama, Japan

Masanobu Suzuki