Nippon Shinyaku Company, Ltd.

Takara Shuzo Co., Inc.

Masanobu Kawamata

Yutaka Takahashi

Koichi Ushimaru

Hirokazu Ushimaru

Hiroshi Enomoto

Yoshiaki Aoyagi

Fusao Ueda

Sho Inoue

Akira Nomura

Hideichi Miyasako

Koichi Nakamichi

Hiroyuki Goshi

Teruya Nakamura

Yoji Ezure

Nobutoshi Ojima

Akira Sano

Shuji Yamane

Kiyotaka Konno

Hideyuki Yasuda

Sodium 1,4-dimethylisopropylazulene-3-sulfonate is stabilized by dissolving it in a suitable solvent and thereafter removing the solvent from the solution by spray-drying or lyophilization.

Stabilization of azulene derivatives

A compound of the formula (I): ##STR1## in which:  is a single bond or a double bond,

Physiologically active substances named SEN-366

2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof in finely pulverized form so that the average particle diameter is 20 microns or less have been found to be particularly useful for the treatment of peptic ulcers. When administered to humans in need thereof, 1 to 4 mg per day has been found effective.

Low dosage compositions of finely pulverized

Liposomes of steryl glucosides and/or steryl glucoside monopalmitates are useful for hemostatic, vascular stabilization and anti-shock effects, particularly in the form of injectable solutions.

Liposome and method of manufacture therefor

Sodium 1,4-dimethylisopropylazulene-3-sulfonate is stabilized by adding to a solution thereof, physiologically non-toxic additives and then removing or separating the solvent therefrom by spray drying or a lyophilization.

2,4-Diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof in finely pulverized form so that the average particle diameter is 20 microns or less have been found to be particularly useful for the treatment of peptic ulcers.

Finely pulverized 2,4-diamino-6-(2,5-dichloro-phenyl)-1,3,5-triazine and

A process for producing amorphous preparations of steryl glucoside monopalmitates, wherein steryl glucoside monopalmitates are heated at a temperature above 110.degree. C up to about 145.degree. C or the compounds are dissolved in an organic solvent in which they are soluble with a solvent which is then distilled off, and the compounds then pulverized and mixed with physiologically harmless organic or inorganic fine particles in a proportion of 0.5 times (by weight) of the compounds or more, thereby homogeneously dispersing the amorphous compounds in the fine particles or uniformtly adsorbing the compounds on the fine particles, and the resulting preparations which have hemostatic properties and are readily absorbable upon ingestion. The starting steryl glucoside monopalmitates are obtained in crystalline form as from soy beans or other vegetable sources.

Process for producing easily absorbable amorphous steryl glucoside

Sterol glycosides are rendered easily absorbable through the digestive tract by dissolving or dispersing the steroid glycoside with heating into a water solution of a polymer or polymers and then removing the solvent.

Process for preparing easily absorbable sterol glycoside

A method of preparing aqueous solutions of sterol glycosides and their ester derivatives characterized by solubilizing sterol glycosides and their ester derivatives by (1) dissolving said sterol glycoside or ester in a lower aliphatic alcohol and subsequently adding a hydrophilic non-ionic surface active agent, or (2) mixing or dissolving said sterol glycoside or ester with or in a lipophilic surface active agent or its solution in an organic solvent miscible with water and subsequently adding a hydrophilic surface active agent.

Growing community of inventors

Kyoto, Japan

Masanobu Kawamata