Snow Brand Milk Products Co., Ltd.

Daiichi Pharmaceutical Co., Ltd.

Masamichi Nakakoshi

Makoto Yoshihama

Nobuo Miyata

Shoji Nakayama

Koji Tamura

Shin Nomoto

Shinichi Shimada

Noboru Kawaguchi

Junji Nakamura

Rolf Wolfgang Hartmann

Susumu Ishiguro

Gosei Kawanishi

Yoshikazu Ikeda

Yasuyoshi Takeshita

Motohide Seya

Masayuki Okue

Yuzo Yagi

Nobuo Ogane

Tadayoshi Koyama

Kohji Tamura

Bertil Wachall

Naomi Kito

Kunio Tomitsuka

Akinori Wakaiki

Yasunari Saito

Keiji Hayashi

Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C -lyase inhibiting activity, thromboxan A synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.

Dihydronaphthalene compounds

Benzofuranone derivatives and a method for producing them

Tetralone or benzopyranone derivatives and a method for producing them

Particular hexahydropyrano [3,2-b] [1,4] benzothiazine derivatives represented by the following general formula (I) or pharmaceutically acceptable acid-addition salts thereof. ##STR1## The compounds can facilitate the metabolic turnover of inositol phospholipids at a hippocampus playing an important part in memory, and improve cerebral function leading the memory. The compounds can be utilized as agents for activating brain metabolism and improving cerebral function.

Hexahydropyrano [3,2-B] [1,4] benzothiazine derivative

Novel 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives are disclosed. The group of these compounds has possibility of being utilized as an intermediate for the synthesis of progesterone derivatives having ovulation-inhibiting activity. These compounds themselves have also cell differentiation activity for M1 cells.

Method for preparing 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives

A process for the preparation in high yield of 14.alpha.-hydroxy-4-androstene-3,6,17-trione which has an aromatase inhibition activity and is useful as an antitumor agent, in which the 6.beta.-hydroxyl group of 6.beta., 14.alpha.-dihydroxy-4-androstene-3,17-dione is selectively oxidized with the aid of visible light energy.

Process for preparing 14-.alpha.-hydroxy-4-androstene-3,6,17-trione

Novel androst-4-ene-3,17-dione derivatives are disclosed. The group of these compounds has biological activities, in particular, the inhibiting activity on human placenta-derived estrogen-synthesizing enzyme. Therefore these compounds are expected to be utilized in the field of medical care, particularly as anticancer drugs.

Novel androst-4-ene-3,17-dione derivatives and method for preparing same

Novel 7 .beta.-hydroxy-4-pregnene-3,20-dione derivatives and method for

Novel alprenolol derivatives represented by the formula: ##STR1## wherein R is ##STR2## and hydrochlorides thereof are disclosed.

Alprenolol derivatives

Growing community of inventors

Utsunomiya, Japan

Masamichi Nakakoshi