Sumitomo Chemical Company, Limited

Masami Okuno

Iwao Nakatsuka

Akira Yoshitake

Kunio Shiba

Hideo Saji

Akira Yokoyama

Iwoa Nakatsuka

The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof. The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radiopharmaceutical.

Radioactive benzodiazepine derivatives

A radioactive propyl 2-iodospiroperidol of the formula: ##STR1## wherein I* is a radioactive iodine atom. The radioactive compound has a high affinity for dopamine receptors and is very useful as a radioactive diagnostic agent and as a radiopharmaceutical.

Novel radioactive propyl 2-iodospiroperidol and processes for the

The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof. The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radio-pharmaceutical.

A radioactive or non-radioactive 2-iodobutyrophenone derivative the formula: ##STR1## wherein X is a radioactive or non-radioactive iodine atom. The radioactive compound has a high affinity for dopamine receptors and is very useful as a radioactive diagnostic agent and as a radiopharmaceutical, and the non-radioactive compound also as a high affinity for dopamine receptors and is very useful as a neuroleptic, a sedative, an anodyne, a tranquilizer, etc.

Growing community of inventors

Osaka, Japan

Masami Okuno