Daiichi Sankyo Company, Limited

Daiichi Pharmaceutical Co., Ltd.

Microcide Pharmaceuticals, Inc.

Trine Pharmaceuticals, Inc.

Masami Ohtsuka

William John Watkins

Aesop Cho

Ving J Lee

Masanori Ichikawa

Kiyoshi Nakayama

Yoshihiro Shibata

Noriyasu Haginoya

Tomoyuki Tsunemi

Hironao Saito

Hironori Matsunaga

Roger Leger

Monica H Palme

Zhijia J Zhang

Thomas Eric Renau

Suzanne Chamberland

Toshiharu Ohta

Jason Zhang

Haruko Kawato

Yohei Ishida

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.

Imidazopyridin-2-one derivatives

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof. 

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):wherein, Rand Rrepresent hydrogen atom, a halogen atom, hydroxyl group or the like, Wrepresents &#x2014;CH&#x2550;CH&#x2014;, &#x2014;CHO&#x2014;, &#x2014;CHCH&#x2014; or the like; Rrepresents hydrogen atom, a halogen atom, hydroxyl group or an amino group; Rrepresents hydrogen atom, a group of &#x2014;OZR(Zrepresents an alkylene group, a fluorine-substituted alkylene group or a single bond, and Rrepresents a cyclic alkyl group, an aryl group or the like); Wrepresents a single bond or &#x2014;C(R)&#x2550;C(R)&#x2014; (Rand Rrepresent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but Wand Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

Drug efflux pump inhibitor

Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

Efflux pump inhibitors

Growing community of inventors

Tokyo, Japan

Masami Ohtsuka